Detection of antibodies to the nuclear antigen of hepatitis B virus in donors from Yakutia as a method of enhancing viral safety
https://doi.org/10.25789/YMJ.2025.92.18
Abstract
Identifying donors with latent infection and a history of viral hepatitis, followed by their exclusion from donation, is one method for harvesting virus-safe blood components and, consequently, minimizing the risk of post-transfusion complications. To this end, an analysis of the results of a study on antibodies to the hepatitis B core antigen (anti-HBcore) was conducted in donors at the Sakha Republic (Yakutia) Blood Transfusion Center in 2021-2024. During the entire study period the overall detection rate of anti-HBcore was 26.3%, with no statistically significant gender-based difference (25.3% in men vs. 28.2% in women; p = 0.912). Donor age appeared to be one of the main factors influencing anti-HBcore prevalence: the lowest frequency of anti-HBcore was observed in the 21-30 age group – 3.8%, in the 41-50 age group – 58.8%, and in the group over 50 years – 41.0%. Based on the analysis of the obtained results, it is proposed to determine anti-HBcore with each donation for donors over 30-35 years of age.
About the Authors
V. V. Gerasimova
ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»; ГБУ РС(Я) «Станция переливания крови»
Russian Federation
Russian Federation
L. E. Davydova
ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»; ГБУ РС(Я) «Станция переливания крови»
Russian Federation
Russian Federation
A. R. Ermolaev
ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»
Russian Federation
Russian Federation
A. A. Ivanova
ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»
Russian Federation
Russian Federation
N. A. Chulakova
ФГАОУ ВО «Северо-Восточный федеральный университет имени М.К. Аммосова»; ГБУ РС(Я) «Якутская республиканская клиническая больница»
Russian Federation
Russian Federation
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Review
For citations:
Gerasimova V.V., Davydova L.E., Ermolaev A.R., Ivanova A.A., Chulakova N.A. Detection of antibodies to the nuclear antigen of hepatitis B virus in donors from Yakutia as a method of enhancing viral safety. Yakut Medical Journal. 2025;(4):88-91. (In Russ.) https://doi.org/10.25789/YMJ.2025.92.18
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