Association of obesity, C-reactive protein levels, and non-alcoholic fatty liver disease in female residents of Southern Yakutia Clinical Case
https://doi.org/10.25789/YMJ.2025.92.28
Abstract
A study working women in Southern Yakutia to analyze obesity rates and their association with serum C-reactive protein levels and the prevalence of non-alcoholic fatty liver disease revealed that at least half of them are obese. Extreme obesity (class III) is typical for women nearing menopause. Body mass index, waist circumference, and hip circumference are closely correlated with serum C-reactive protein levels, the frequency of elevated C-reactive protein levels, and the incidence of non-alcoholic fatty liver disease. The frequencies of elevated C-reactive protein levels and non-alcoholic fatty liver disease show signs of a complete functional relationship. One-third of the study participants with normal body weight are likely at risk for developing non-alcoholic fatty liver disease and related diseases.
About the Authors
I. V. Kononova
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
S. I. Sofronova
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
A. N. Romanova
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
References
1. Cardiovascular prevention 2022. Russian national guidelines / S.A. Boytsov [et al.] // Russian journal of cardiology. 2023. Vol. 28, No. 5. P. 119-249. DOI:10.15829/1560-4071-2023-5452
2. Sofronova S.I., Romanova A.N. Relationship of non-alcoholic fatty liver disease in patients with arterial hypertension to certain cardio-metabolic risk factors. Yakut Medical Journal. 2024. No. 4 (88). P. 118-121. DOI: 10.25789/YMJ.2024.88.28
3. Cariou B, Byrne CD, Loomba R, Sanyal AJ. Nonalcoholic fatty liver disease as a metabolic disease in humans: A literature review. Diabetes Obes Metab. 2021. No23(5):1069-1083. doi: 10.1111/dom.14322..
4. Chen C, Gong J, Li M et al. High sensitivity C-reactive protein may be a significant predictor of non-alcoholic fatty liver disease in non-obese adults: A four-year retrospective study, Nutrition, Metabolism and Cardiovascular Diseases. 2025. 104224. https://doi.org/10.1016/j.num-ecd.2025.104224.
5. Kesavadev J, Krishnan G, Basanth A. et al. Association of Elevated C-reactive Protein with Body Mass Index and Gender in Individuals with Diabetes: A Cross-sectional Analysis. International Journal of Diabetes and Technology.2025. No 4(1). P. 5-10. DOI: 10.4103/ijdt.ijdt_3_25
6. Kumar R, Porwal YC, Dev N et al. Association of high-sensitivity C-reactive protein (hs-CRP) with non-alcoholic fatty liver disease (NAFLD) in Asian Indians: A cross-sectional study. J Family Med Prim Care. 2020 No 28;9(1). P.390-394. doi: 10.4103/jfmpc.jfmpc_887_19.
7. Ross R, Neeland IJ, Yamashita S et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol. 2020. No16(3). P.177-189. doi: 10.1038/s41574-019-0310-7.
8. Rubino F, Cummings DE, Eckel RH et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025;13(3):221-262. doi: 10.1016/S2213-8587(24)00316-4.
9. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
10. Yang YC, C.E. Walsh, Johnson MP, Belsky DW et al. Life-course trajectories of body mass index from adolescence to old age: Racial and educational disparities. Proc. Natl. Acad. Sci. U.S.A. 118 (17) e2020167118, https://doi.org/10.1073/pnas.2020167118(2021).
Review
For citations:
Kononova I.V., Sofronova S.I., Romanova A.N. Association of obesity, C-reactive protein levels, and non-alcoholic fatty liver disease in female residents of Southern Yakutia Clinical Case. Yakut Medical Journal. 2025;(4):130-133. (In Russ.) https://doi.org/10.25789/YMJ.2025.92.28
Views:
31
JATS XML
Email this article 