Influence of anaesthesia on the immune status of patients with malignant neoplasms in oropharyngeal region
D. N. Vasileiv,
D. E. Kulbakin,
E. L. Choynzonov,
S. V. Avdeev,
M. N. Stakheyeva,
L. W. Gerdt,
A. A. Lee,
D. Y. Azovskaya,
D. A. Shishkin,
A. V. Shvetsova https://doi.org/10.25789/YMJ.2024.87.01
Abstract
The purpose of the study was to evaluate the effect of pre-carbohydrate loading and perioperative administration of dalargin on immunity indicators in patients who underwent surgery for malignant neoplasms of the oropharyngeal region. The multicomponent general anesthesia was conducted in the control group (n=29). It is established that the use of enkephalin, dalargin, as a component of anesthetic support in the perioperative period in the surgical treatment of malignant neoplasms of the oropharyngeal region is associated with a lower concentration of pro-inflammatory interleukins, an increase in IgG concentration compared with endotracheal multicomponent anesthesia and may contribute to the activation of an antitumor immune response.
About the Authors
D. N. Vasileiv
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Vasiliev Danil N. – MD, Department of Anesthesiology and Resuscitation, , Researcher ID (WOS): HZH-9155-2023.
Tomsk
D. E. Kulbakin
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Kulbakin Denis E. – MD, DSc, Senior Researcher, Head of Department of Head and Neck Tumors, Researcher ID (WOS): D-1151-2012.
Tomsk
E. L. Choynzonov
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Choynzonov Evgeny L. – MD, DSc, Professor, Member of the Russian Academy of Sciences, Director of the Cancer Research Institute, Tomsk NRMC; Department of Head and Neck Tumors. Researcher ID (WOS): P-1470-2014. Author ID (Scopus): 6603352329.
Tomsk
S. V. Avdeev
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Avdeev Sergey V. – MD, DSc, Department of Anesthesiology and Resuscitation, SPIN-код: 8433-4153. Researcher ID (WOS): S-6135-2017. Author ID (Scopus): 7003292835.
Tomsk
M. N. Stakheyeva
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Stakheyeva Marina N. – MD, DSc, Laboratory of molecular oncology and immunology.
Tomsk
L. W. Gerdt
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Gerdt Lyubov V. – MD, Laboratory of molecular oncology and im-
Munology.
A. A. Lee
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Lee Andrey A. – MD, Head of Department of Anesthesiology and Resuscitation.
Tomsk
D. Y. Azovskaya
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Azovskaya Daria Y. – MD, Department of Head and Neck Tumors. Researcher ID (WOS): GRJ-3131-2022.
Tomsk
D. A. Shishkin
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Shishkin Dmitrij Yu. – MD, Department of Head and Neck Tumors, Researcher ID (WOS): D-1186-2012.
Tomsk
A. V. Shvetsova
Cancer Research Institute, Tomsk NRMC
Russian Federation
Russian Federation
Shevtsova Anna V. – Nurse of Department of Anesthesiology and Resuscitation.
Tomsk
References
1. The effect of dalargin on the proliferation of multipotent mesenchymal cells of dermal fibroblasts and human osteosarcoma cells in vitro / Vasiliev A.V. [et al.] // Genes and cells. 2014. V. 9. No. 4. P. 76-80. doi: 10.23868/gc120391
2. Matveeva L.V., Mosina L.M. The role of cytokines of the interleukin-1 family in gastric carcinogenesis // Bulletin of the Russian Academy of Medical Sciences. 2012. No. 11. P. 59-65. doi: 10.15690/vramn.v67i11.473
3. Ovechkin A.M. Managerial analysis, its pathophysiological significance and youth assistance // Regional organization and treatment of acute pain. 2008. No. 2. P. 49-62
4. Plasma indicators of expression of mediators of the acute phase reaction in the initial stages of adaptation to the antiorthostatic position / Larina O.N. [et al.] // Cytokines and inflammation. 2011. V. 10. No.1. P. 3-5.
5. A new tumor promotion pathway and its inhibitors / Fujiki H. [et al.] // Cancer Detect Prev. 1994. V. 18. No.1. P. 1-7.
6. Anesthetics, immune cells, and immune responses / Kurosawa S. [et al.] // J Anesth. 2008. V.22. No.3. P.263-277. doi:10.1007/s00540-008-0626-2
7. Barton B.E. IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation // Immunologic Research. 2001. V. 23. No.1. P. 41-58. doi: 10.1385/IR:23:1:41
8. Cancer metastasis: building a framework / Gupta G.P. [et al.] // Cell. 2006. V. 127. No.4. P. 679-695. doi:10.1016/j.cell.2006.11.001
9. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression /sasada T. [et al.] // Cancer. 2003. V. 98. No.5. P. 1089-1099. doi:10.1002/cncr.11618
10. comparison of the effect of spinal anesthesia and general anesthesia on 5-year tumor recurrence rates after transurethral resection of bladder tumors / Choi W.J. [et al.] // Oncotarget. 2017. V.8, No.50. P. 87667-87674. doi: 10.18632/oncotarget.21034
11. Effects of general anesthesia with combined epidural anesthesia on inflammatory response in patients with early-stage gastric cancer undergoing tumor resection / Liu W. [et al] // Exp Ther Med. 2019. V.17. No.1. P.35–40. doi: 10.3892/etm.2018.6898
12. Garmaeva D.V. Effect of Leu-Enkephalin Analogue on the Myeloid Compartment of the Blood System in Hypothyroid White Rats under Stress Conditions // Bull Exp Biol Med. 2022. V. 173. No.1. P. 1-4. doi:10.1007/s10517-022-05479-2
13. Haroutounian S. Postoperative opioids, endocrine changes, and immuno suppression // PAIN Reports. 2018. V.3. No.2. P.640-644. doi:10.1097/PR9.0000000000000640
14. Insulin resistance: a marker of surgical stress / Thorell A. [et al.] // Curr Opin Clin Nutr Metab Care. 1999. V.2. No.1. P. 69-78. doi:10.1097/00075197-199901000-00012
15. Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes / He J. [et al.] // Mol Endocrinol. 2006. Vol. 20, No.1. P. 114-124. doi:10.1210/me.2005-0107
16. Kim R. Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence // J Transl Med. 2018. V. 16. No.1. P.8. doi:10.1186/s12967-018-1389-7
17. Longterm immune dysfunction after radiotherapy to the head and neck area / Verastegui E.L. [et al.] // Int Immunopharmacol. 2003. V. 3, No.8. P. 1093–1104. doi:10.1016/S1567-5769(03)00013-4
18. Naugler W.E., Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer // Trends in Molecular Medicine. 2008. V. 14. No.3. P. 109-119. doi: 10.1016/j.molmed.2007.12.007.
19. Opioid requirement, opioid receptor expression, and clinical outcomes in patients with advanced prostate cancer / Zylla D. [et al.] // Cancer. 2013. V.119. No.23. P. 4103-4110. doi:10.1002/cncr.28345
20. Role of Amino Acid Arginine and Nitric Oxide in Mechanisms of Cytoprotective Effect of Non-Opiate Leu-Enkephalin Analogue In Vitro /sazonova E.N. [et al.] // Bull Exp Biol Med. 2021. V.172. No.2. P. 270-275. doi: 10.1007/s10517-021-05374-2
21. Shalapour S., Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil // J Clin Invest. 2015. V. 125. No.9. P.3347-3355. doi:10.1172/JCI80007
22. Singh P.P., Voleti B., Agrawal A. A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter // J Immunol. 2007. V. 178, No.11. P. 7302-7309. doi:10.4049/jimmunol.178.11.7302
23. Stimulation of tumour growth by wound-derived growth factors // Br J Cancer. 1999. V. 79. No.9-10. P. 1392-1398. doi:10.1038/sj.bjc.6690223
24. The Effects of Anesthetics and Perioperative Medications on Immune Function: A Narrative Review / Ackerman R.S. [et al.] // Anesth Analg. 2021. V. 133. No.3. P. 676-689. doi:10.1213/ANE.0000000000005607
25. The effects of surgical trauma on colorectal liver metastasis / Georges C. [et al.] //surg Endosc. 2007. V. 21. No.10. P. 1817-1819. doi:10.1007/s00464-007-9290-0
26. The influence of surgical trauma on experimental metastasis / Murthy S.M. [et al.] // Cancer. 1989. V. 64, No.10. P. 2035-2044. doi:10.1002/1097-0142(19891115)64:10<2035::aid-cn-cr2820641012>3.0.co;2-l.
27. The perioperative period is an underutilized window of therapeutic opportunity in patients with colorectal cancer / van der Bij G.J. [et al.]
28. // Ann Surg. 2009. Vol. 249, No.5. P. 727-734. doi:10.1097/SLA.0b013e3181a3ddbd
29. The prognostic value of procalcitonin, C-reactive protein and cholesterol in patients with an infection and multiple organ dysfunction / Tachyla S.A. [et al.] // Korean J Anesthesiol. 2017. V. 70. No.3. P. 305-310. doi:10.4097/kjae.2017.70.3.305
30. Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation / Komori A. [et al.] // Cancer Res. 1993. V. 53. No.9. P. 1982-1985.
Review
For citations:
Vasileiv D.N., Kulbakin D.E., Choynzonov E.L., Avdeev S.V., Stakheyeva M.N., Gerdt L.W., Lee A.A., Azovskaya D.Y., Shishkin D.A., Shvetsova A.V. Influence of anaesthesia on the immune status of patients with malignant neoplasms in oropharyngeal region. Yakut Medical Journal. 2024;(3):5-9. https://doi.org/10.25789/YMJ.2024.87.01
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