Age-related dynamics of the lipid profile in the indigenous population of Yakutia

Abstract

The age and gender indicators of lipid metabolism and glucose were analyzed in a cohort of indigenous people aged 20 to 95 years. The frequency of dyslipidemia was studied. Blood lipids in long-livers are close to those of 20-29 year olds. High cholesterol and triglycerides in men occur at the age of 40-49 years, in women 10 years later. In men in all age groups, the glucose content is higher, the antiatherogenic fraction of lipids is lower. The higher is weight, the higher is the level of glucose, triglycerides, cholesterol and lower the level of HDL cholesterol. Changes in the lipid profile in men occur from 30 to 69 years, in women - from 50 to 79 years. The peak incidence of dyslipidemia, obesity and the amount of total cholesterol and glucose occurs at the age of 50-59 years, which classifies this group on the basis of serious metabolic disorders as a risk group for the development of pathologies as an obstacle to surviving to the age of long-livers.