Characteristic and comorbide associations of asthenic syndrome in Khakasia schoolchildren
https://doi.org/10.25789/YMJ.2020.71.10
Abstract
The diagnostic value of determining the concentrations of bone remodeling markers (type I collagen C-telopeptide, P1NP, 25-OH vitamin D) in the blood serum of patients with rheumatoid arthritis (RA) by constructing ROC curves to predict the development of osteoporosis (OP) was under study.
It was revealed, that these bone remodeling markers are of good quality and can be used to predict the development of OP in patients with RA.
About the Authors
Yu. R. AkhverdyanRussian Federation
B. V. Zavodovsky
Russian Federation
Yu. V. Polyakova
Russian Federation
L. E. Seewordova
Russian Federation
E. V. Papichev
Russian Federation
References
1. Dydykina I.S. The study of local and generalized bone loss in patients with rheumatoid arthritis / I.S. Dydykina, P.O. Kozhevnikova // Nauchno-prakticheskaya revmatologiya. – 2019. –V. 57, № 3. – Р.328-332.
2. Carey J.J. Biochemical markers of bone turnover / J.J. Carey, A.A. Licata, M.F. Delaney // Clin Rev Bone Miner Metab. – 2006. - №4. – Р.197–212.
3. Clarke B. Normal bone anatomy and physiology / B. Clarke // Clin J Am Soc Nephrol. -2008. - №3. – Р.131–139.
4. Davis J. The Relationship between Precision-Recall and ROC Curves / J. Davis, M. Goadrich // Proc. Of 23 International Conference on Machine Learning. - Pittsburgh, PA, 2006.
5. Difference between total and intact assays for N-terminal propeptide of type I procollagen reflects degradation of pN-collagen rather than denaturation of intact propeptide / M.-K. Koivula, V. Ruotsalainen, M. Björkman, S. Nurmenniemi, R. Ikäheimo, K. Savolainen [et al.] // Ann Clin Biochem. – 2010. - №47. – Р.67–71.
6. Garnero P. Evaluation of a fully automated serum assay for total N-terminal propeptide of type I collagen in postmenopausal osteoporosis / P. Garnero, P, Vergnaud, N. Hoyle // Clin Chem. – 2008. - №54. – Р.188–96.
7. Li Y. Vitamin D receptor (VDR) genetic polymorphisms associated with intervertebral disc degeneration / Y. Li, J. Zhu, C. Gao, B. Peng // J Genet Genome. – 2015. - V. 42, №4. Р.135–140.
8. Zaidi M. Skeletal remodelling in health and disease / M. Zaidi // Nature Med. – 2007. №13. – Р.791–801.
Review
For citations:
Akhverdyan Yu.R., Zavodovsky B.V., Polyakova Yu.V., Seewordova L.E., Papichev E.V. Characteristic and comorbide associations of asthenic syndrome in Khakasia schoolchildren. Yakut Medical Journal. 2020;(3):39-41. (In Russ.) https://doi.org/10.25789/YMJ.2020.71.10









