Signs of polar T3 syndrome in young men in Yakutia
https://doi.org/10.25789/YMJ.2024.85.01
Abstract
The aim of the study was to search for seasonal variations in the levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) in young men in Yakutia, where there are strong changes in climatic parameters in the winter-spring period (from -41.8°C to -0.2°C). Seasonal variations between winter and spring were found for fT3, where in winter its levels were lower – 6.48±0.31 pmol/L than in spring 6.88±0.1 pmol/L (p=0.005). There were no statistically significant seasonal variations for TSH (U=97; p=0.914) and sv.T4 (U=47; p=0.112). Winter-spring seasonal variations of fT3 detected in this study there are signs of polar T3 syndrome in young men in Yakutia. To search for the causes of the detected seasonal variation, a correlation analysis of the levels of TSH, fT3 and fT4 was carried out depending on daylength and atmospheric air temperature. As a result, a correlation between fT3 and fT4 with the daylight (fT3: R=0.339, p=0.03; fT4: R=-0.346, p=0.01) and with air temperature (fT3: R=0.295, p=0.05; fT4: R=-0.296, p=0.04). No correlations were found with TSH levels (daylight: R=-0.06, p=0.69; air temperature: R=-0.09, p=0.559). Thus, the residents of Yakutia have signs of polar T3 syndrome, which can be associated with both a short light day and low atmospheric temperatures in winter. The results obtained may indicate an increase in the absorption of T3 at the tissue level when exposed to cold.
About the Authors
A. A. Nikanorova
Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
NIKANOROVA Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics
N. A. Barashkov
Federal State Budgetary Scientific Institution Yakutsk Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
BARASHKOV Nikolay Alekseevich – Candidate of biological sciences, Head of laboratory of Molecular genetics
V. G. Pshennikova
Federal State Budgetary Scientific Institution Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
PSHENNIKOVA Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics
S. S. Nakhodkin
Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
NAKHODKIN Sergey Sergeyevich – scientific researcher of the Research Laboratory of Molecular Biology Institute of Natural Sciences
S. A. Fedorova
Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
FEDOROVA Sardana Arkadievna – Doctor in Biology, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences
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Review
For citations:
Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Nakhodkin S.S., Fedorova S.A. Signs of polar T3 syndrome in young men in Yakutia. Yakut Medical Journal. 2024;(1):5-8. https://doi.org/10.25789/YMJ.2024.85.01
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