Analysis of polymorphic variants of serotonin and gamma-aminobutyric acid receptor genes in patients with type 2 diabetes mellitus
https://doi.org/10.25789/YMJ.2023.84.02
Abstract
An analysis of polymorphic variants of the serotonin receptor genes HTRD rs674386, HTR1F rs56398417, HTR2A rs6313, HTR3A rs1062613, HTR2C rs6318 and the GABRA2 rs279845 gene in T2D patients living in the Republic of Belarus was carried out. As a result of the study of 6 loci of neurotransmitter genes, protective markers CT and CC genotypes of the rs1062613 locus of the HTR3A gene (OR= 0.73, Pcor_FDR=0.0007) and GC and CC risk genotypes of the rs6318 locus of the HTR2C gene (OR=2.21, Pcor_FDR=0.0045) among women, the CC genotype is also risky for men (R=4.05, Pcor_FDR=0.0045). Analysis of combinations of genotypes and alleles revealed combinations of increased and decreased risk of T2D. The analysis of ROC curves showed that the studied loci and such variables as sex, age of the examined and BMI can be used to assess the prognostic significance of T2D AUC=83.4% (95% CI 83.5-87.4).
Keywords
type 2 diabetes mellitus,
neurotransmitter system,
serotonin receptors,
gamma-aminobutyric acid receptor
Supporting agencies: The study was partly supported by the Russian Science Foundation (No. 22-25- 00010)
About the Authors
O. V. Kochetova
Institute of Biochemistry and Genetics of Ufa Federal Research Centre of the Russian Academy of Science
Russian Federation
Russian Federation
Kochetova Olga Vladimirovna – PhD in Biology, Senior Researcher
Ufa
Web of Science Researcher ID A-2035-2014
D. S. Avzaletdinova
Bashkir State Medical University
Russian Federation
Russian Federation
Avzaletdinova Diana Shamilevna – PhD, Associate Professor
Ufa
G. F. Korytina
Institute of Biochemistry and Genetics of Ufa Federal Research Centre of the Russian Academy of Science
Russian Federation
Russian Federation
Korytina Gulnaz Faritovna – Doctor of Biological Sciences, Associate Professor, chief researcher
Web of Science ResearcherID A-1688-2014
T. V. Viktorova
Bashkir State Medical University
Russian Federation
Russian Federation
Viktorova Tatyana Viktorovna – MD, Professor, Head of the Department
Author ID: 90113
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For citations:
Kochetova O.V., Avzaletdinova D.S., Korytina G.F., Viktorova T.V. Analysis of polymorphic variants of serotonin and gamma-aminobutyric acid receptor genes in patients with type 2 diabetes mellitus. Yakut Medical Journal. 2023;(4):9-12. https://doi.org/10.25789/YMJ.2023.84.02
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