Specific features of aortic wall calcification in patients with thoracic aortic aneurysm
https://doi.org/10.25789/YMJ.2023.84.03
Abstract
Histological assessment of calcification patterns in different sites of the ascending aorta in patients with thoracic aortic aneurysm has been performed using alizarin red S staining. Biopsy specimens from 67 patients (47 males, 20 females, mean age 56,9±11,1 years) with thoracic aortic aneurysm from three different sites of ascending aorta were taken intraoperatively. Calcific precipitates were diffusely distributed mainly in the tunica media of the vessel. The mean calcium percentage was: for the sinotubular junction (zone 1) - 7.85 [2.2; 15.4]%, mid-ascending aorta (zone 2) – 10.45 [3.83; 22.35]%, proximal aortic arch (zone 3) – 10.95 [4.65; 18.63]% (p=0.216). Patients with maximum calcification level in zone 3 were younger (53 [41; 62] years) than patients in whom the maximum calcification was detected in zone 2 and zone 1.
Supporting agencies: This research was funded by the Russian Science Foundation (grant No. 22-25-00701).
About the Authors
S. A. Shipulina
Tomsk National Research Medical Center, Russian
Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
Shipulina Sofia Alexandrovna – post-graduate student, Laboratory of Population Genetics, Research Institute of Medical Genetics; research assistant, Laboratory of Cell and Microfluidic Technologies
I. A. Goncharova
Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Goncharova Irina Alexandrovna – PhD in Biology, research associate, Laboratory of Population Genetics, Research Institute of Medical Genetics
D. S. Panfilov
Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
Panfilov Dmitry Sergeevich – MD, senior research associate, Department of Cardiovascular Surgery, Cardiology Research Institute; research assistant,
Department of Hospital Surgery with the Course
of Cardiovascular Surgery
B. N. Kozlov
Tomsk National Research Medical Center, Russian
Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
Kozlov Boris Nikolaevich – MD, Head of Department of Cardiovascular Surgery, Cardiology Research Institute; Professor, Department of Hospital Surgery with a Course of Cardiovascular Surgery
I. V. Sukhodolo
Siberian State Medical University
Russian Federation
Russian Federation
Sukhodolo Irina Vladimirovna – MD, Professor, Professor at Morphology and General Pathology Department
M. S. Nazarenko
Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Nazarenko Maria Sergeevna – MD, Head of Laboratory of Population Genetics, Research Institute of Medical Genetics
References
1. Dolzhenko A., Richter T., Sagalovsky S. Vascular calcification, atherosclerosis and bone loss (osteoporosis): new pathophysiological mechanisms and future perspectives for pharmacological therapy // Almanac of Clinical Medicine. 2016; 4(44): 513-534. DOI: https://doi.org/10.18786/2072-0505-2016-44-4-513-534
2. Chumachenko P.V. [et al.]. Inflammatory infiltrates, vasa vasorum, and endothelial NO-synthase in the wall of thoracic aortic aneurysm. Archive of pathology. 2019; 81(5): 45-52. DOI: 10.17116/patol20198105145
3. Laughlin G. A. [et al.] Abdominal aortic diameter and vascular atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery. 2011; 4 (41): 481–487. DOI: 10.1016/j.ejvs.2010.12.015
4. Hatemi A. C. [et al.]. Association between ascending aortic diameter and coronary artery dilation: a demographic data analysis. The Journal of International Medical Research. 2016; 6 (44): 1349–1358. DOI: 10.1177/0300060516666623
5. Craiem D. [et al.]. Association of calcium density in the thoracic aorta with risk factors and clinical events. European Radiology. 2020; 7 (30): 3960–3967. DOI: 10.1007/s00330-020-06708-w
6. Samaha H. [et al.]. Calcification of the ascending aorta, left heart valves and coronaries: associated diseases and a new classification. Future Cardiology. 2022; 9 (18): 687–695. DOI: 10.2217/fca-2022-0016
7. Chau K. H., Bender J. R., Elefteriades J. A. Silver lining in the dark cloud of aneurysm disease // Cardiology. 2014; 4 (128): 327–332. DOI: 10.1159/000358123
8. Cho I.-J. [et al.]. Correlation between coronary artery calcium score and aortic diameter in a high-risk population of elderly male hypertensive patients. Coronary artery disease. 2014; 8 (25): 698–704. DOI: 10.1097/MCA.0000000000000150
9. Desai M. Y., Cremer P. C., Schoenhagen P. Thoracic aortic calcification: diagnostic, prognostic, and management considerations. JACC: Cardiovascular Imaging. 2018; 7 (11): 1012–1026. DOI: 10.1016/j.jcmg.2018.03.023
10. Wasteson P. [et al.]. Developmental origin of smooth muscle cells in the descending aorta in mice. Development (Cambridge, England). 2008; 10 (135): 1823–1832. DOI: 10.1242/dev.020958
11. Dyer L. A., Kirby M. L. The role of secondary heart field in cardiac development. Developmental Biology. 2009; 2 (336): 137–144. DOI: 10.1016/j.ydbio.2009.10.009
12. Chironi G. [et al.]. Early thoracic aorta enlargement in asymptomatic individuals at risk for cardiovascular disease: determinant factors and clinical implication. Journal of Hypertension. 2010; 10 (28): 2134–2138. DOI: 10.1097/HJH.0b013e32833cd276
13. Chowdhury M. M. [et al.]. Editor’s choice - Calcification of thoracic and abdominal aneurysms is associated with mortality and morbidity European Journal of Vascular and Endovascular Surgery: The Official Journal of the European Society for Vascular Surgery. 2018;1 (55): 101–108. DOI: 10.1016/j.ejvs.2017.11.007
14. Jiang X. [et al.] Fate of the mammalian cardiac neural crest. Development (Cambridge, England). 2000; 8 (127): 1607–1616. DOI: 10.1242/dev.127.8.1607
15. Schindelin J. [et al.] Fiji: an open-source platform for biological-image analysis. Nature Methods. 2012; 7 (9): 676–682. DOI: 10.1038/nmeth.2019
16. Lanzer P. [et al.] Medial arterial calcification: JACC state-of-the-art review. Journal of the American College of Cardiology. 2021;11 (78): 1145–1165. DOI: 10.1016/j.jacc.2021.06.049
17. Leroux-Berger M. [et al.]Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin.. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research. 2011;7 (26): 1543–1553. DOI: 10.1002/jbmr.382
18. Thomas I. C. [et al.] Progression of calcium density in the ascending thoracic aorta is inversely associated with incident cardiovascular disease events. European Heart Journal Cardiovascular Imaging. 2018; 12 (19): 1343–1350. DOI: 10.1093/ehjci/jey007
19. Rivera J. J. [et al.] Relationship of thoracic aortic calcium to coronary calcium and its progression (from the Multi-Ethnic Study of Atherosclerosis [MESA]). The American Journal of Cardiology. 2009; 11 (103): 1562– 1567. DOI: 10.1016/j.amjcard.2009.02.004
20. Senser E. M., Misra S., Henkin S. Thoracic aortic aneurysm: a clinical review. Cardiology Clinics. 2021; 4 (39): 505–515. DOI: 10.1016/j.ccl.2021.06.003
21. Simionescu A., Simionescu D. T., Vyavahare N. R. Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-β1. The American Journal of Pathology. 2007; 1 (171): 116–123. DOI: 10.2353/ajpath.2007.060930
22. Hermann D. M. [et al.] Thoracic aortic calcification is associated with incident stroke in the general population in addition to established risk factors. European Heart Journal. Cardiovascular Imaging. 2015; 6 (16): 684–690. DOI: 10.1093/ehjci/jeu293
23. Kapustin A. N. [et al.]. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circulation Research. 2015; 8 (116): 1312–1323. DOI: 10.1161/CIRCRESAHA.116.305012
Review
For citations:
Shipulina S.A., Goncharova I.A., Panfilov D.S., Kozlov B.N., Sukhodolo I.V., Nazarenko M.S. Specific features of aortic wall calcification in patients with thoracic aortic aneurysm. Yakut Medical Journal. 2023;(4):13-16. https://doi.org/10.25789/YMJ.2023.84.03
Views:
18
Email this article 