Markers of bone metabolism and polymorphism of the еNOS gene in the children's population of the Eastern Siberia region with diseases of the musculoskeletal system
https://doi.org/10.25789/YMJ.2023.82.28
Abstract
We have examined bone metabolism in children living in Eastern Siberia; the aim was to substantiate markers of musculoskeletal diseases. As a result, we have established that children with diseases of the musculoskeletal system have statistically significantly higher levels of N-osteocalcin, ionized calcium and alkaline phosphatase in blood than children without them (р < 0.05). The obtained results indicate that the G894T polymorphism of the candidate endothelial NO-synthase gene, associated with a high frequency of the T allele of the eNOS G894T gene is one of the etiological factors in the development of bone metabolism disorders, and the marker itself should be attributed to the predictors of the formation of pathology of the musculoskeletal system in children of the region from Eastern Siberia.
About the Authors
N. V. Zaitseva
Federal Research Center for Medical and Preventive Technologies for Public Health Risk Management
Russian Federation
Russian Federation
Perm
A. A. Subbotina
Federal Research Center for Medical and Preventive Technologies for Public Health Risk Management
Russian Federation
Russian Federation
Perm
O. V. Dolgikh
Federal Research Center for Medical and Preventive Technologies for Public Health Risk Management
Russian Federation
Russian Federation
Perm
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Review
For citations:
Zaitseva N.V., Subbotina A.A., Dolgikh O.V. Markers of bone metabolism and polymorphism of the еNOS gene in the children's population of the Eastern Siberia region with diseases of the musculoskeletal system. Yakut Medical Journal. 2023;(2):118-121. https://doi.org/10.25789/YMJ.2023.82.28
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