Нейровоспаление и функционирование головного мозга: возможные последствия у детей, инфицированных COVID-19
https://doi.org/10.25789/YMJ.2023.82.25
Аннотация
В статье рассмотрены научные данные, основанные на современной литературе о нейровоспалении и функционировании головного мозга у детей, инфицированных COVID-19. Многочисленные исследования показали, что как и при других вирусных инфекциях, таких как краснуха, грипп и цитомегаловирус, SARS-CoV-2 вызывает массивное высвобождение провоспалительных цитокинов, которые влияют на функцию микроглии, что может быть критичным для развития мозга. Кроме того, в исследованиях сообщалось о транзиторном тиреотоксикозе, вызванном SARS-CoV-2, с вторичным аутоиммунным гипотиреозом, который может остаться незамеченным во время беременности.
Об авторах
А. А. ГуляевРоссия
Артем Александрович Гуляев, студент 6 курса
Благовещенск
К. А. Дробяскина
Россия
Ксения Анатольевна Дробяскина, студентка 3 курса
Благовещенск
И. А. Синякин
Россия
Иван Алексеевич Синякин, студент 5 курса; лаб.-исслед.
Благовещенск
Т. А. Баталова
Россия
Татьяна Анатольевна Баталова, д. б. н., проф., зав. кафедрой
Благовещенск
Список литературы
1. Анализ показателей эндогенной интоксикации у пациентов с внебольничной пневмонией, ассоциированной с COVID-19 / А. В. Кучер, С. В. Ходус, О. Б. Приходько // Бюлл. физиологии и патологии дыхания. 2022. № 84. С. 63-69. DOI 10.36604/1998-5029-2022-84-63-69.
2. Итоги пандемии COVID-19 на территории Амурской области / Жуковец И.В., Андриевская И. А., Кривощекова Н. А. [и др.] // Тезисы XVI Общероссийского семинара «Репродуктивный потенциал России: версии и контраверсии» и IX Общероссийской конференции «FLORES VITAE. Контраверсии неонатальной медицины и педиатрии», Сочи, 07–10 сентября 2022 года. М.: Редакция журнала StatusPraesens, 2022. С. 27-28.
3. Эхоструктурная и патоморфологическая характеристика ликворных путей головного мозга у доношенных новорожденных с врожденной цитомегаловирусной инфекцией / Гориков И.Н., Сомова Л.М., Андриевская И.А., Заболотских Т.В., Ишутина Н.А., Довжикова И.В., Баталова Т.А. // Бюлл. физиологии и патологии дыхания. 2019;(71):94-99. DOI: 10.12737/article_5c89a9e47a4580.34275288
4. Abduljabbar MA, Afifi AM. Congenital hypothyroidism. J Pediatr Endocrinol Metab. 2012;25:13-29. DOI: 10.1515/jpem.2011.408
5. ACE2 expression and activity are enhanced during pregnancy / Levy A, Yagil Y, Bursztyn M, Barkalifa R, Scharf S, Yagil C// Am J Physiol Regul Integr Comp Physiol. 2008;295((6)):R1953–61. DOI: 10.1152/ajpregu.90592.2008
6. Age-dependent effects in the transmission and control of COVID-19 epidemics / Davies NG, Klepac P, Liu Y, Prem K, Jit M, Eggo RM // Nat Med. 2020;26((8)):1205-11. DOI: 10.1038/s41591-020-0962-9
7. Alcohol consumption modulates host defense in rhesus macaques by altering gene expression in circulating leukocytes. / Barr T, Girke T, Sureshchandra S, Nguyen C, Grant K, Messaoudi I // J Immunol. 2016;196((1)):182-95. DOI: 10.4049/jimmunol.1501527
8. Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice. /Elliott R, Li F, Dragomir I, Chua MM, Gregory BD, Weiss SR // PLoS One. 2013;8((9)):e75346. DOI: 10.1371/journal.pone.0075346
9. Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease / Margina D, Ungurianu A, Purdel C, Nitulescu GM, Tsoukalas D, Sarandi E, et al // Food Chem. 2020;143:111558. DOI: 10.1016/j.fct.2020.111558
10. A pneumonia outbreak associated with a new coronavirus of probable bat origin/Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al// Nature. 2020;579((7798)):270-3. DOI: 10.1038/s41586-020-2012-7
11. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria / Hoyme HE, May PA, Kalberg WO, Kodituwakku P, Gossage JP, Trujillo PM, et al // Pediatrics. 2005;115((1)):39–47. DOI: 10.1542/peds.2004-0259
12. Bazan NG. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol. 2005;32((1)):89-103. DOI: 10.1385/MN:32:1:089
13. Bernal J. Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007;3((3)):249-59. DOI: 10.1038/ncpendmet0424
14. Chen Z, Zhong D, Li G. The role of microglia in viral encephalitis: a review. J Neuroinflammation. 2019;16((1)):76. DOI: 10.1186/s12974-019-1443-2
15. Early inflammatory status related to pediatric obesity/Marginean CO, Melit LE, Ghiga DV, Marginean MO// Front Pediatr. 2019;7:241. DOI: 10.3389/fped.2019.00241
16. Effects of 3,3',5-triiodothyronine on microglial functions / Mori Y, Tomonaga D, Kalashnikova A, Furuya F, Akimoto N, Ifuku M, et al / Glia. 2015;63((5)):906-20. DOI: 10.1002/glia.22792
17. Effects of toll-like receptor 4 antagonists against cerebral vasospasm after experimental subarachnoid hemorrhage in mice /Kawakita F, Fujimoto M, Liu L, Nakano F, Nakatsuka Y, Suzuki H. // Mol Neurobiol. 2017;54((8)):6624-33. DOI: 10.1007/s12035-016-0178-7
18. Environmental signals on microglial function during brain development, neuroplasticity, and disease./Chagas LDS, Sandre PC, Ribeiro E Ribeiro NCA, Marcondes H, Oliveira Silva P, Savino W, et al. // Int J Mol Sci. 2020;21((6)):2111. DOI: 10.3390/ijms21062111
19. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms / Baig AM, Khaleeq A, Ali U, Syeda H // ACS Chem Neurosci. 2020;11((7)):995-8. DOI: 10.1021/acschemneuro.0c00122
20. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues / Li MY, Li L, Zhang Y, Wang XS // Infect Dis Poverty. 2020;9((1)):45. DOI: 10.1186/s40249-020-00662-x
21. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology / Chang PK, Khatchadourian A, McKinney RA, Maysinger D. // J Neuroinflammation. 2015;12:34. DOI: 10.1186/s12974-015-0244-5
22. Farhadi S, Ovchinnikov RS. The relationship between nutrition and infectious diseases : a review. Biomed Biotechnol Res J. 2018:2.
23. Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections / McGill J, Meyerholz DK, Edsen-Moore M, Young B, Coleman RA, Schlueter AJ, et al // J Immunol. 2009;182((12)):7803-8. DOI: 10.4049/jimmunol.0803881
24. Functional role of dietary intervention to improve the outcome of COVID-19: a hypothesis of work / Messina G, Polito R, Monda V, Cipolloni L, Di Nunno N, Di Mizio G, et al/ Int J Mol Sci. 2020;21((9)):3104. DOI: 10.3390/ijms21093104
25. Guerri C, Bazinet A, Riley EP. Foetal alcohol spectrum disorders and alterations in brain and behaviour. Alcohol Alcohol. 2009;44((2)):108-14. DOI: 10.1093/alcalc/agn105
26. Human milk proresolving mediators stimulate resolution of acute inflammation / Arnardottir H, Orr SK, Dalli J, Serhan CN // Mucosal Immunol. 2016;9((3)):757–66. DOI: 10.1038/mi.2015.99
27. IFN-γ-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair. /Kunis G, Baruch K, Rosenzweig N, Kertser A, Miller O, Berkutzki T, et al. // Brain. 2013;136((Pt 11)):3427–40. DOI: 10.1093/brain/awt259
28. Immunological implications of pregnancy-induced microchimerism. /Kinder JM, Stelzer IA, Arck PC, Way SS.//Nat Rev Immunol. 2017;17((8)):483-94. DOI: 10.1038/nri.2017.38
29. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment/Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT// J Neuroinflammation. 2008;5:10. DOI: 10.1186/1742-2094-5-10
30. Influenza virus-cytokine-protease cycle in the pathogenesis of vascular hyperpermeability in severe influenza / Wang S, Le TQ, Kurihara N, Chida J, Cisse Y, Yano M, et al // J Infect Dis. 2010;202((7)):991-1001. DOI: 10.1086/656044
31. Kawasaki disease with predominant central nervous system involvement / Tabarki B, Mahdhaoui A, Selmi H, Yacoub M, Essoussi AS // Pediatr Neurol. 2001;25((3)):239-41. DOI: 10.1016/s0887-8994(01)00290-9
32. Maternal alcohol abuse and neonatal infection. /Gauthier TW, Drews-Botsch C, Falek A, Coles C, Brown LA. // Alcohol Clin Exp Res.2005;29((6)):1035-43. DOI: 10.1097/01.alc.0000167956.28160.5e
33. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study/Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ // Clin Endocrinol. 2003;59((3)):282-8. DOI: 10.1046/j.1365-2265.2003.01822.x
34. Medina AE. Fetal alcohol spectrum disorders and abnormal neuronal plasticity. Neuroscientist. 2011;17((3)):274–87. DOI: 10.1177/1073858410383336
35. Microglia development follows a stepwise program to regulate brain homeostasis / Matcovitch-Natan O, Winter DR, Giladi A, Vargas Aguilar S, Spinrad A, Sarrazin S, et al // Science. 2016;353((6301)):aad8670. DOI: 10.1126/science.aad8670
36. Microglia require CD4 T cells to complete the fetal-to-adult transition / Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, et al // Cell. 2020;182((3)):625–e24. DOI: 10.1016/j.cell.2020.06.026
37. Microglia, the missing link in maternal immune activation and fetal neurodevelopment; and a possible link in preeclampsia and disturbed neurodevelopment?/Prins JR, Eskandar S, Eggen BJL, Scherjon SA. // J Reprod Immunol. 2018;126:18-22. DOI: 10.1016/j.jri.2018.01.004
38. Multisystem inflammatory syndrome in U.S. children and adolescents/The CDCC-RT. Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. // N Engl J Med. 2020;383((4)):334-46. DOI: 10.1056/NEJMoa2021680
39. Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19 / Kanberg N, Ashton NJ, Andersson LM, Yilmaz A, Lindh M, Nilsson S, et al. // Neurology. 2020;95((12)):e1754–9. DOI: 10.1212/WNL.0000000000010111
40. Neuroprotection by a caspase inhibitor in acute bacterial meningitis / Braun JS, Novak R, Herzog KH, Bodner SM, Cleveland JL, Tuomanen EI // Nat Med. 1999;5((3)):298-302. DOI: 10.1038/6514
41. Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes / Madore C, Nadjar A, Delpech JC, Sere A, Aubert A, Portal C, et al. // Brain Behav Immun. 2014;41:22-31. DOI: 10.1016/j.bbi.2014.03.021
42. Nutritional restriction of omega-3 fatty acids alters topographical fine tuning and leads to a delay in the critical period in the rodent visual system/de Velasco PC, Mendonça HR, Borba JM, Andrade da Costa BL, Guedes RC, Navarro DM, et al// Exp Neurol. 2012;234((1)):220-9. DOI: 10.1016/j.expneurol.2011.12.032
43. Omega-3 fatty acids in boys with behavior, learning, and health problems / Stevens LJ, Zentall SS, Abate ML, Kuczek T, Burgess JR // Physiol Behav. 1996;59((4-5)):915-20. DOI: 10.1016/0031-9384(95)02207-4
44. Ornoy A, Weinstein-Fudim L, Ergaz Z. Prenatal factors associated with autism spectrum disorder (ASD) Reprod Toxicol. 2015;56:155-69. DOI: 10.1016/j.reprotox.2015.05.007
45. Pagnin D, Zamboni Grecco ML, Furtado EF. Prenatal alcohol use as a risk for attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. 2019;269((6)):681-7. DOI: 10.1007/s00406-018-0946-7
46. Paolicelli RC, Ferretti MT. Function and dysfunction of mcroglia during brain development: consequences for synapses and neural circuits. Front Synaptic Neurosci. 2017;9:9. DOI: 10.3389/fnsyn.2017.00009
47. Parenteral fish oil: an adjuvant pharmacotherapy for coronavirus disease 2019? /Torrinhas RS, Calder PC, Lemos GO, Waitzberg DL// Nutrition. 2020;81:110900. DOI: 10.1016/j.nut.2020.110900
48. PIMS-TS Study Group and EUCLIDS and PERFORM Consortia (2020). Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 / Whittaker, E., Bamford, A., Kenny, J., Kaforou, M., Jones, C. E., Shah, P., Ramnarayan, P., Fraisse, A., Miller, O., Davies, P., Kucera, F., Brierley, J., McDougall, M., Carter, M., Tremoulet, A., Shimizu, C., Herberg, J., Burns, J. C., Lyall, H., Levin, M. et al. // JAMA, 324(3), 259–269. DOI: 10.1001/jama.2020.10369
49. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn / Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. // JAMA. 2020;323((18)):1846-48. DOI: 10.1001/jama.2020.4621
50. Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes / Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, et al // Transl Psychiatry. 2017;7((9)):e1229. DOI: 10.1038/tp.2017.182
51. Regulation of learning and memory by meningeal immunity: a key role for IL-4 / Derecki NC, Cardani AN, Yang CH, Quinnies KM, Crihfield A, Lynch KR, et al. // J Exp Med. 2010;207((5)):1067–80. DOI: 10.1084/jem.20091419
52. Regulation of microglial development: a novel role for thyroid hormone / Lima FR, Gervais A, Colin C, Izembart M, Neto VM, Mallat M. // J Neurosci. 2001;21((6)):2028-38. DOI: 10.1523/JNEUROSCI.21-06-02028.2001
53. Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells / Tremblay ME, Zhang I, Bisht K, Savage JC, Lecours C, Parent M, et al. // J Neuroinflammation. 2016;13((1)):116. DOI: 10.1186/s12974-016-0580-0
54. Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity / Berbel P, Navarro D, Ausó E, Varea E, Rodríguez AE, Ballesta JJ, et al. // Cereb Cortex. 2010;20((6)):1462-75. DOI: 10.1093/cercor/bhp212
55. Sallenave JM, Guillot L. Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in covid-19: key therapeutic targets? Front Immunol. 2020;11:1229. DOI: 10.3389/fimmu.2020.01229
56. Sandre PC, de Velasco PC, Serfaty CA. The impact of low omega-3 fatty acids diet on the development of the visual system. In: Preedy VR, Watson RR, editors. Handbook of nutrition, diet, and the eye. 2<sup>nd</sup> ed. Vol. 1. London: Elsevier; 2019. p. 641.
57. SARS-CoV-2 infects human neural progenitor cells and brain organoids / Zhang BZ, Chu H, Han S, Shuai H, Deng J, Hu YF, et al // Cell Res. 2020;30((10)):928-31. DOI: 10.1038/s41422-020-0390-x
58. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 / Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S / J Virol. 2008;82((15)):7264–75. DOI: 10.1128/JVI.00737-08
59. Severe COVID-19 during pregnancy and possible vertical transmission / Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. // Am J Perinatol. 2020;37((8)):861-5. DOI: 10.1055/s-0040-1710050
60. Single cell analysis of ACE2 expression reveals the potential targets for 2019-nCoV/Zhu Y, Jiang M, Gao L, Huang X // Preprints 2020. 2020 2020020221.
61. Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic/Ruggeri RM, Campenni A, Siracusa M, Frazzetto G, Gullo D // Hormones. 2020:1-3. DOI: 10.1007/s42000-020-00230-w
62. The impact of illness on social networks: implications for transmission and control of influenza / Van Kerckhove K, Hens N, Edmunds WJ, Eames KT// Am J Epidemiol. 2013;178((11)):1655-62. DOI: 10.1093/aje/kwt196
63. The microglial innate immune receptor TREM2 is required for synapse elimination and normal brain connectivity / Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, et al. // Immunity. 2018;48((5)):979–e8. DOI: 10.1016/j.immuni.2018.04.016
64. The pathophysiological role of microglia in dynamic surveillance, phagocytosis and structural remodeling of the developing CNS / Arcuri C, Mecca C, Bianchi R, Giambanco I, Donato R. // Front Mol Neurosci. 2017;10:191. DOI: 10.3389/fnmol.2017.00191
65. TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders / Pascual M, Montesinos J, Montagud-Romero S, Forteza J, Rodríguez-Arias M, Miñarro J, et al// J Neuroinflammation. 2017;14((1)):145. DOI: 10.1186/s12974-017-0918-2
66. Transplacental transmission of SARS-CoV-2 infection /Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J, et al. // Nat Commun. 2020;11((1)):3572. DOI: 10.1038/s41467-020-17436-6
67. Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms / Zhou Z, Kang H, Li S, Zhao X // J Neurol. 2020;267((8)):2179-84. DOI: 10.1007/s00415-020-09929-7
68. Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders / Hoyme HE, Kalberg WO, Elliott AJ, Blankenship J, Buckley D, Marais AS, et al // Pediatrics. 2016;138((2)):e20154256. DOI: 10.1542/peds.2015-4256
69. Zika virus infects human fetal brain microglia and induces inflammation. /Lum FM, Low DK, Fan Y, Tan JJ, Lee B, Chan JK, et al. // Clin Infect Dis. 2017;64((7)):914-20. DOI: 10.1093/cid/ciw878
Рецензия
Для цитирования:
Гуляев А.А., Дробяскина К.А., Синякин И.А., Баталова Т.А. Нейровоспаление и функционирование головного мозга: возможные последствия у детей, инфицированных COVID-19. Якутский медицинский журнал. 2023;(2):106-111. https://doi.org/10.25789/YMJ.2023.82.25
For citation:
Gulyaev A.A., Drobyaskina K.A., Sinyakin I.A., Batalova T.A. Neuroinflammation and brain functioning: possible implications in children infected with COVID-19. Yakut Medical Journal. 2023;(2):106-111. https://doi.org/10.25789/YMJ.2023.82.25