Communication of genes interleukine-5, α - and β-linkage of its receptor polymorphism with atopic bronchial asthma in children of RS(Y)
Abstract
Results of the analysis of association of polymorphic variants of genes interleukine-5 (IL5), α - and β – linkage of its receptor (IL5RA, IL5RB) with bronchial asthma (BА) are presented. Research is spent in group of 103 unrelated patients with atopic BA, Yakuts on ethnicity and 223 healthy unrelated Yakuts. In group of BA patients prevalence of allele IL5R β * G1972 polymorphic variant G1972A of gene IL5R β and genotype IL5R β *G/*G is revealed. Statistically significant values on the raised risk of BA development have been noted for genotype IL5R α *G/*A polymorphic variant G-80A of gene IL5R α. Polymorphic variant С-703Т of gene IL5 with risk of atopic BA development in the Yakut population was not associated.
About the Authors
N. A. Solovieva
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
L. E. Nikolaeva
РБ №1 НЦМ РС(Я)
Russian Federation
Russian Federation
N. R. Maksimova
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Solovieva N.A., Nikolaeva L.E., Maksimova N.R. Communication of genes interleukine-5, α - and β-linkage of its receptor polymorphism with atopic bronchial asthma in children of RS(Y). Yakut Medical Journal. 2009;(2):139-141. (In Russ.)
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