Association of the G-308A TNF gene polymorphism with clinically important cardiovascular endophenotypes and longevity
Abstract
Association of the G-308A TNF gene polymorpHism with several clinically important cardiovascular endophenotypes such as arterial blood pressure measurements and cardiac parameters had been studied. Allele and genotype frequences were compared between patients with arterial hypertension (n=231), healthy controls (n=331) and nonagenarians (mean age=92, n=131). No significant differences among those groups were revealed. In patients’ group with arterial hypertension combined with diabetes type 2 A-308 allele frequency was higher in left ventriculi hypertrophy (LVH) subgroup than in patients without LVH: 18% vs 8% (p=0,033). Left ventricular remodeling index was significantly higher in AA genotype carriers as compared to GA and GG genotypes: 0,552±0,057 vs 0,433±0,008 and 0,429±0,018, appropriately (p=0,013). An association of G-308A TNF gene polymorpHism with twenty-four-hour monitoring blood pressure measurements was revealed in hypertensive patients without diabetes.
Thus G-308A TNF polymorpHism was associated with several important cardiovascular endophenotypes but not with longevity.
About the Authors
O. J. Bychkova
НИИ МГ СО РАМН
Russian Federation
Russian Federation
O. A. Makeeva
НИИ МГ СО РАМН
Russian Federation
Russian Federation
I. V. Tsimbaljuk
Сибирский Государственный медицинский университет
Russian Federation
Russian Federation
K. V. Puzyrev
НИИ кардиологии СО РАМН
Russian Federation
Russian Federation
E. N. Pavljukova
НИИ кардиологии СО РАМН
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ МГ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Bychkova O.J., Makeeva O.A., Tsimbaljuk I.V., Puzyrev K.V., Pavljukova E.N., Puzyrev V.P. Association of the G-308A TNF gene polymorphism with clinically important cardiovascular endophenotypes and longevity. Yakut Medical Journal. 2009;(2):124-127. (In Russ.)
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