Involvement of cytokine signal molecules genes in pathogenesis of bronchial asthma and opisthorchiasis
Abstract
Aim. Analysis of relationship between the gene polymorpHisms of cytokine signal molecules with bronchial asthma and opisthorchiasis.
Materials and methods. Polymorphisms of TBX21, STAT2, STAT4, SOCS7, PIAS4, PIAS3 were analised by PCR-RELF genotyping in the patients with bronchial asthma (BA), opisthorchiasis an their combination.
Results. Association between the polymorphism rs12756687 PIAS3 with function of lung among the patients with BA was shown, evidence of association was observed between the polymorphism rs2066807 STAT4 and BA combined with opisthorchiasis, association of the polymorphism rs3890580 SOCS7 with IgE level of the patients with opisthorchiasis but not with BA.
Conclusion. These data can serve a basis for further study of susceptibility to helminth infection and modifying effect of opisthorchiasis on BA course.
About the Authors
I. V. Saltykova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. B. Frejdin
НИИ МГ СО РАМН
Russian Federation
Russian Federation
E. J. Bragina
НИИ МГ СО РАМН
Russian Federation
Russian Federation
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ МГ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Saltykova I.V., Frejdin M.B., Bragina E.J., Ogorodova L.M., Puzyrev V.P. Involvement of cytokine signal molecules genes in pathogenesis of bronchial asthma and opisthorchiasis. Yakut Medical Journal. 2009;(2):121-123. (In Russ.)
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