Level of immune response IFNG, STAT1 and MCP1 genes expression in conditions of various antigenic loading
Abstract
In this review, we compared IFNG, STAT1 and MCP1 expression levels in human peripheral blood mononuclear cells (PBMC) stimulated by PHA (phytohemagglutinin), TDM (trechalose 6,6’-dimicolate, cord-factor from Mycobacterium tuberculosis), LPS (lipopolysacharide from Salmonella enterica serotype enteritidis), IFN-γ (interferon gamma), IL-4 (interleukin 4) and their combination. It was shown that inductor TDM had insignificanf influence on expression level of innate immunity genes, but the combination TDM and IFN-γ increased their expression. Increased gene expression level of IFNG, STAT1, MCP1 expression levels were also detected in PBMC exposured with LPS, IL-4 and their combination.
About the Authors
D. S. Ozhegova
ГУ “Сибирский государственный медицинский университет Федерального агенства по здравоохранению и социальному развитию”
Russian Federation
Russian Federation
M. B. Frejdin
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
I. A. Goncharova
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Ozhegova D.S., Frejdin M.B., Goncharova I.A., Puzyrev V.P. Level of immune response IFNG, STAT1 and MCP1 genes expression in conditions of various antigenic loading. Yakut Medical Journal. 2009;(2):118-120. (In Russ.)
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