Role of polymorphic VNTR locus in DRD4 gene in development of alcohol and narcotic dependence and formation of personal features in healthy individuals
Abstract
Sociability-related personality traits are assumed to be intermediate phenotypes predisposing to addiction. In order to reveal alcoholism and opiate addiction risk markers we conducted comparative analysis of allele and genotype distribution of VNTR loci in promotor region of DRD4 gene between patients of Tatar, Russian, Bashkir, Yakut, Evenk ethnicity and matched controls. DRD4 S-allele was revealed to be the risk marker for opiate addiction in Tatar male, while both DRD4 S/S-genotype and DRD4 S-allele were demonstrated to be the risk markers for alcoholism in Tatar and Russian males. As a result of analysis of variance considering gender and ethnical differences and performed in healthy individuals subjected to personality traits assessment, STATistically significant increase in Extraversion in Tatar male and in Persistence in Russian male DRD4 S-allele carriers was observed. Revealed findings point to the presence of positive correlation between decreased dopaminergic activity and higher risk of alcohol and opiate addiction, increase in Extraversion and decrease in Persistence.
About the Authors
A. V. Kazantseva
Институт биохимии и генетики УНЦ РАН
Russian Federation
Russian Federation
G. G. Fashutdinova
Институт биохимии и генетики УНЦ РАН
Russian Federation
Russian Federation
S. S. Kulichkin
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
E. K. Khusnutdinova
Институт биохимии и генетики УНЦ РАН
Russian Federation
Russian Federation
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Review
For citations:
Kazantseva A.V., Fashutdinova G.G., Kulichkin S.S., Khusnutdinova E.K. Role of polymorphic VNTR locus in DRD4 gene in development of alcohol and narcotic dependence and formation of personal features in healthy individuals. Yakut Medical Journal. 2009;(2):107-110. (In Russ.)
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