Polymorphism of some genes of hemostasis system and hemorrhagic stroke in Yakuts
Abstract
For the first time an analysis of contribution of alleles of haemostasis genes, encoding fibrinogen alpha (FGA), fibrinogen beta (FGB) and tissue plasminogen activator (TPA), in genetic susceptibility to and clinical aspects of hemorrhagic stroke (HS) was performed in ethnic Yakuts. HS patients compared to controls demonstrated significant increase of frequency of FGA4266А/А genotype carriage: 26,9% vs 16,1% (p=0,04, OR=1,9, CI 1,0 - 3,8) and corresponding decrease of FGA4266G allele carriage: 73,1% vs 83,9% (p=0,04, OR =0,5, CI 0,3 - 1,0). We identified tri-allelic combination: FGB−249C; FGA4266G; TPA−7351C, which carriage is significantly differed in HS patients with different types of haemorrhage.
About the Authors
S. A. Chugunova
ЯНЦ КМП СО РАМН;
РБ№2
Russian Federation
Russian Federation
M. A. Sudomoina
ГОУ ВПО “Российский государственный медицинский университет” Росздрава
Russian Federation
Russian Federation
T. Ya. Nikolaeva
МИ ЯГУ
Russian Federation
Russian Federation
M. G. Parfenov
ГОУ ВПО “Российский государственный медицинский университет” Росздрава
Russian Federation
Russian Federation
O. J. Makarycheva
ФГУ “Российский кардиологический научно-производственный комплекс” Росмедтехнологий
Russian Federation
Russian Federation
A. B. Geht
ГОУ ВПО “Российский государственный медицинский университет” Росздрава
Russian Federation
Russian Federation
O. O. Favorova
ГОУ ВПО “Российский государственный медицинский университет” Росздрава
Russian Federation
Russian Federation
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Review
For citations:
Chugunova S.A., Sudomoina M.A., Nikolaeva T.Ya., Parfenov M.G., Makarycheva O.J., Geht A.B., Favorova O.O. Polymorphism of some genes of hemostasis system and hemorrhagic stroke in Yakuts. Yakut Medical Journal. 2009;(2):105-107. (In Russ.)
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