Connection of transcription factor gene GATA4 polymorphism with echocardiographic parameters in population and patients with ischemic heart disease
Abstract
PolymorpHisms of GATA4 gene, encoding cardiac specific transcription factor, influencing genetic expression in the heart at the different stages of biological development, as well as at the pathological conditions have been studied. Genotypes on GATA4 tagging SNPs rs804271, rs8191515 and rs2898293 were identified in control group with normal echocardiographic parameters (N=280) and in patients with ischemic heart disease (n=130). Association of rs804271 GG genotype with higher left ventricular mass index in woman of control group had been revealed: 96,0±12,7 g/m2 in TT carriers versus 90,3±12,2 g/m2 and 90,4±12,1 g/m2 with genotypes GG и GT, accordingly (р=0,037). rs2898293 genotypes were associated with ejection fraction in patients with ischemic heart disease (p=0,05).
About the Authors
O. G. Ivanova
НИИ МГ СО РАМН
Russian Federation
Russian Federation
O. A. Makeeva
НИИ МГ СО РАМН
Russian Federation
Russian Federation
A. A. Leznev
НИИ кардиологии СО РАМН
Russian Federation
Russian Federation
I. V. Tsimbaljuk
ГУ ВПО «Сибирский государственный медицинский университет»
Russian Federation
Russian Federation
V. V. Shipulin
НИИ кардиологии СО РАМН
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ МГ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Ivanova O.G., Makeeva O.A., Leznev A.A., Tsimbaljuk I.V., Shipulin V.V., Puzyrev V.P. Connection of transcription factor gene GATA4 polymorphism with echocardiographic parameters in population and patients with ischemic heart disease. Yakut Medical Journal. 2009;(2):102-104. (In Russ.)
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