Role of estrogen receptor-α gene polymorphisms (ESR1) in development of postmenopausal osteoporosis in Volga-Ural region of Russia
Abstract
The analysis of c.454-397T>C, c.454-351A>G и (ТА)n polymorphic loci of ESR1 gene in postmenopausal women Tatars and Russians origin from Volga-Ural region and association of the allelic variants and their combination with the risk of fracture development and BMD, estradiol level has been conducted. The association of ESR1*G*A genotype of c.454-351A>G polymorphic locus with the low risk of osteoporotic fractures has been discovered (OR=0,61; 95%CI 0,46-0,95), and allele ESR1*G – with the high risk of osteoporotic fractures (OR=1,57; 95%CI 1,06-2,3) in Russians women. The associations of ESR1*A*A genotype and ESR1*T*A haplotype of ESR1 gene with high level of estradiol has been shown in Tatars women.
About the Authors
R. I. Khusainova
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
L. I. Selezneva
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
E. A. Fazlyeva
Женская консультация №5
Russian Federation
Russian Federation
R. Z. Nurlygayanov
Городская больница №21
Russian Federation
Russian Federation
D. D. Nadyrshina
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
O. M. Lesnyak
Уральская медицинская академия
Russian Federation
Russian Federation
E. K. Khusnutdinova
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
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Review
For citations:
Khusainova R.I., Selezneva L.I., Fazlyeva E.A., Nurlygayanov R.Z., Nadyrshina D.D., Lesnyak O.M., Khusnutdinova E.K. Role of estrogen receptor-α gene polymorphisms (ESR1) in development of postmenopausal osteoporosis in Volga-Ural region of Russia. Yakut Medical Journal. 2009;(2):96-99. (In Russ.)
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