The analysis of mutations in genes BRCA1, CHEK2, NBS1 in patients with breast cancer from RS (Y)
Abstract
We carried out screening of patients with breast cancer (n=60) and healthy population controls (n=120) of Republic Sakha (Yakutia) on presence of mutations 5382insC, 4153delA, С61G in BRCA1gene, mutations IVS2+1 G>A, CHEK2dele9,10 (5kb), 1100delC in CHEK2 gene and 657del5 in NBN gene. These mutations have not been found in the cohort.
About the Authors
A. R. Farahtdinova
Институт биохимии и генетики УНЦ РАН
Russian Federation
Russian Federation
S. A. Fedorova
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
T. I. Nikolaeva
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
P. M. Ivanov
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
M. A. Bermisheva
ИБГ УНЦ РАН
Russian Federation
Russian Federation
T. Doerk
Ганноверская медицинская школа
Germany
Germany
E. K. Khusnutdinova
ИБГ УНЦ РАН
Russian Federation
Russian Federation
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Review
For citations:
Farahtdinova A.R., Fedorova S.A., Nikolaeva T.I., Ivanov P.M., Bermisheva M.A., Doerk T., Khusnutdinova E.K. The analysis of mutations in genes BRCA1, CHEK2, NBS1 in patients with breast cancer from RS (Y). Yakut Medical Journal. 2009;(2):91-93. (In Russ.)
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