The role of social factors in the formation of congenital heart disease in the Republic of Sakha (Yakutia)
https://doi.org/10.25789/YMJ.2023.81.27
Abstract
The article presents the results of the study of the association of some socio-demographic factors with risk of congenital heart disease in children in the Republic of Sakha (Yakutia). The analysis was carried out on the basis of the Perinatal Center of the Republican Hospital No.1-NCM). The study includes all cases of congenital defects among newborns born alive in two time periods – from 2001-2003 and 2011-2013. In the first period, 697 cases were registered, in the second period there were 1127 cases of congenital heart disease.
The first group included newborns with persistent fetal communications without signs of heart failure, without expansion of the heart cavities and without hemodynamic disorders. The second group was represented by newborns with congenital heart disease with signs of heart failure and functional class of various degrees. This group was divided by severity of heart failure and functional class stages into two subgroups which were 2A and 2B respectively.
The factors such as the education of parents, the number of births in the history, the presence of a full and incomplete family, were analyzed.
The compared groups were not statistically significantly different by age of the parents. The median values of the mothers’ age at the time of birth of a child with congenital heart disease were 27 years in the first group, 26 years in the 2A group, and 28 years in the 2B group. The median age of the father in all groups was 29 years.
The structure of categories of social status is represented mainly by employees, non-workers, workers and students. An analysis of the parents of the education factor as a possible predictor of the birth of a child with congenital heart disease was also conducted.
According to the results of the study, social factors affecting the risk of birth of children with congenital heart defects were an incomplete family without a sign of marriage (registered and unregistered marriage), the level of education of the mother in the case of simple heart defects, the number of births and the social status of the mother in complex diseases.
Supporting agencies: The work was performed within the research theme "Physical development and health status of the child population in the Far North (by the example of Yakutia)" (state registration number: 1021062411641-9-3.2.3), within the state assignment of the Ministry of Science and Education of the Russian Federation (FSRG-2023-0003).
About the Authors
M. S. Savvina
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Savvina Maya Semyonovna – PhD, senior researcher of the laboratory Monitoring of the state of children's health
T. I. Nelunova
Yakutsk Republican Clinical Hospital; St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Nelunova Tuyara Ivanovna – cardiologist of the Perinatal Center; PhD student
T. E. Burtseva
Medical Institute, M.K. Ammosov North-Eastern Federal University; Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Burtseva Tatiana Egorovna – MD, Professor, Department of Pediatrics and Pediatric Surgery; Head of the Child Health Monitoring Laboratory
T. M. Klimova
Medical Institute, M.K. Ammosov North-Eastern Federal University; Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Klimova Tatiana Mikhailovna – PhD in Medical Sciences, Associate Professor, Department of Pharmacology and Pharmacy; Associate Professor, Senior Research Specialist
V. B. Egorova
Medical Institute, M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Egorova Vera Borisovna – PhD in Medical Sciences, Associate Professor, Department of Pediatrics and Pediatric Surgery
V. G. Chasnyk
FSBEI HE St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Chasnyk Vyacheslav Grigorievich – MD, Professor, head of the Department of Hospital Pediatrics
References
1. The influence of social, medical and environmental factors on the formation of sporadic congenital heart defects / Shabaldin A.V. [et al.] // Russian Bulletin of Perinatology and Pediatrics. 2018. No. 1. P. 14-21. DOI: 10.21508/1027-4065-63-1-14-21.
2. Saperova E.V., Vakhlova I.V. Congenital heart defects in children: prevalence, risk factors, mortality // Issues of modern pediatrics. 2017. Vol. 2. No.16. P. 126-133. DOI: 10.15690/vsp.v16i2.1713.
3. Safiullina A.R., Yakovleva L.V. Analysis of risk factors for the development of congenital septal heart defects // Modern problems of science and education. 2012. No.4. P. 119-122.
4. Factors shaping the health of modern children and adolescents / Grishina O.P., Trankovskaya L.V., Semenov E.V. [et al.] // Pacific Medical Journal. 2020. No. 3. P. 19-24. DOI: 10.34215/160911752020-3-19-24.
5. Children’s Health, The Nation’s Wealth: Assessing and Improving Child Health / National Research Council (US); Institute of Medicine (US); Washington (DC): National Academies Press (US) // Influences on Children’s Health - 2004. – 3.
6. Congenital Heart Disease: Causes, Diagnosis, Symptoms, and Treatments / Sun R. [et al.] // Cell Biochem Biophys. 2015. Jul. 72(3):857. P. 60. DOI: 10.1007/s12013-015-0551-6.
7. Effect of Maternal Antidepressant Use During the Pre-pregnancy/Early Pregnancy Period on Congenital Heart Disease: A Prospective Cohort Study in Central China / Sun M. [et al.] // Front Cardiovasc Med. 2022. Jul 5. 9:916882. DOI: 10.3389/fcvm.2022.916882.
8. Global prevalence of congenital heart disease in school-age children: a meta-analysis and systematic review / Liu Y. [et al] // BMC Cardiovasc Disord. 20, 488 (2020). https://doi.org/10.1186/s12872-020-01781-x
9. National Birth Defects Prevention Study. Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011 / Bolin E.H. [et al.] // J. Pediatr. 2022. Jan (240). P. 79-86. DOI: 10.1016/j.jpeds.2021.09.005.
10. National Birth Defects Prevention Study. Maternal Antihypertensive Medication Use and Congenital Heart Defects: Updated Results From the National Birth Defects Prevention Study / Fisher S.C. [et al.] // Hypertension. 2017. May. 69(5). P. 798-805. DOI: 10.1161/Hypertensionaha.116.08773.
11. Neighbourhood maternal socioeconomic status indicators and risk of congenital heart disease / Miao, Q. [et al.] // BMC Pregnancy Childbirth. 21, 72 (2021). https://doi.org/10.1186/s12884-020-03512-8
12. Maternal Overweight and Obesity and Risk of Congenital Heart Defects / Persson M. [et al.] // J Am Coll Cardiol. 2019. Jan 8. 73(1). P. 44-53. DOI: 10.1016/j.jacc.2018.10.050.
13. Paternal age and offspring congenital heart defects: a national cohort study / Su X.J., Yuan W., Huang G.Y., Olsen J., Li J. // PLoS One. 2015. Mar 25. 10(3): e0121030. DOI: 10.1371/journal.pone.0121030.
14. Prepregnancy Diabetes and Offspring Risk of Congenital Heart Disease: A Nationwide Cohort Study / Øyen N. [et al.] // Circulation 2016. Jun 7. 133(23). P. 2243-53. DOI: 10.1161/Circulationaha.115.017465.
Review
For citations:
Savvina M.S., Nelunova T.I., Burtseva T.E., Klimova T.M., Egorova V.B., Chasnyk V.G. The role of social factors in the formation of congenital heart disease in the Republic of Sakha (Yakutia). Yakut Medical Journal. 2023;(1):112-116. https://doi.org/10.25789/YMJ.2023.81.27
Views:
6
Email this article 