Intensity of local processes of free radical oxidation in red lichen planus of the oral mucosa

Abstract

 Materials and methods of research. 66 patients with a diagnosis of CPL COPR and 33 practically healthy individuals were examined. To characterize the intensity of SRO in the main and control groups, oral fluid was taken into test tubes after preliminary rinsing of the oral cavity with 10 ml of 0.9% sodium chloride solution. The intensity of free radical oxidation processes in the oral fluid was characterized by chemiluminescence (CML) on the LS 50B "PERKIN ELMER" spectrometer. Statistical processing of the results was carried out using methods of variational statistics.

 Results and discussion. Studies of chemiluminescence of mixed saliva in patients with CPL SOPR showed an increase in the generation of oxygen radicals and lipid peroxides: the Ssp value, confirming the intensity of production of toxic radicals, exceeded the identical indicator of the control group by 1.4 times (p< 0.05). Against the background of intensive generation of radical products (H) of mixed saliva in the main group, the indicator is 2.42 times (p<0.05) higher compared to the same indicator in practically healthy individuals, there was a decrease in the level of antioxidant antiradical protection (Sind-2) by 1.66 times (p<0.05), which indicates insufficient activity of the antioxidant defense system (AOS) of a patient with CPL SOPR. Chemiluminescence studies have shown that patients with CPL COPD revealed an imbalance between the processes of SRO and antioxidant protection, this is due to an increase in oxidant load and a decrease in antioxidant resources in mixed saliva in the main group compared with identical data in practically healthy individuals. The results obtained indicate the generation of free radical reactions in the group with CPL of the COPR.

Conclusion. An imbalance in the ratio of the processes of "formation of active metabolites – destruction of active metabolites" indicates hyperproduction of toxic SRO products in mixed saliva in patients with CPL COPR and disruption of work in the AOS system. The study of the activity of the SRO processes and the AOS system can be a condition for increasing the effectiveness of the therapy, by making adjustments to the standard treatment regimens of this category of patients, taking into account the functional state of the body's antioxidant barrier