Primary multiple non-hereditary malignant neoplasms
https://doi.org/10.25789/YMJ.2024.88.24
Abstract
Carcinogenesis is based on a multistage process of changes, malignant transformation and progression, which includes DNA damage and dysfunction of the immune system. Damage to certain parts of genes involved in mitosis, cell death or DNA repair is reflected in an increase in the mutation load. After accumulation of a sufficient number of mutations, control over cell function is disrupted, which leads to the development of cancer. In recent years, an increase in the frequency of multiple primary neoplasms has been noted. The review presents the main risk factors that to one degree or another affect the development of polyneoplasia.
About the Authors
Yu. M. PaderovRussian Federation
Kh. L. Mavidi
Russian Federation
L. D. Zhuikova
Russian Federation
L. V. Pikalova
Russian Federation
M. V. Zavyalova
Russian Federation
D. S. Pismenny
Russian Federation
A. V. Zavyalov
Russian Federation
G. A. Kononova
Russian Federation
O. A. Ananina
Russian Federation
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Review
For citations:
Paderov Yu.M., Mavidi Kh.L., Zhuikova L.D., Pikalova L.V., Zavyalova M.V., Pismenny D.S., Zavyalov A.V., Kononova G.A., Ananina O.A. Primary multiple non-hereditary malignant neoplasms. Yakut Medical Journal. 2024;(4):103-106. (In Russ.) https://doi.org/10.25789/YMJ.2024.88.24