Features of the endometrial microbiome of infertile women and its effect on the viability of the "implantation window" phase
https://doi.org/10.25789/YMJ.2022.80.06
Abstract
Changes in the endometrial microbiome (dysbiotic type) were more often combined with dyschronism phenomena (inconsistency in the rate of the gland maturation with the secretory phase of the menstrual cycle) in women than with secretory changes. The data obtained allow us to state the dysbiotic type of microbiota appears to be a marker of violation of the morphological characteristics of the endometrium during the "implantation window" phase, mainly against the background of a chronic inflammatory process. The dysbiotic profile of the endometrium in infertile women is the cause of a violation of molecular mechanisms necessary for adequate blastocyst implantation. The studying endometrial microbiota increases the likelihood of predicting reproductive outcomes before embryo transfer and choosing an effective treatment strategy when changing quantitative and qualitative species characteristics
About the Authors
M. I. Polina
Medical Center for Women's Health (Moscow), Peoples' Friendship University of Russia
Russian Federation
Russian Federation
Polina Miroslava Leonidovna – PhD in Medical Sciences, Assistant Professor of the Department of Obstetrics and Gynaecology, Medical Center for Women's Health (Moscow), Medical Institute of the Peoples' Friendship University of Russia
I. I. Vityazeva
National Medical Research Center of Endocrinology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Vityazeva Irina Ivanovna – MD, Head. Department
P. N. Zakharova
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Zakharova Praskovya Nikolaevna – post-graduate student of the of the Department of Obstetrics and Gynecology, Faculty of Postgraduate Training of Doctors, Medical Institute
N. I. Douglas
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Douglas Natalya Ivanovna – MD, head. Department of Obstetrics and Gynecology, Medical Institute
References
1. Wee B.A., Thomas M., Sweeney E.L. [et al.] A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women. Aust. N. Z. J. Obstet. Gynaecol. 2018; 58: 341–348. doi: 10.1111/ajo.12754.
2. Baker J.M., Chase D.M., Herbst-Kralovetz M.M. Uterine Microbiota: Residents, Tourists, or Invaders? Front. Immunol. 2018; 9: 208.
3. Fang R.L., Chen L.X., Shu W.S. [et al.] Barcoded sequencing reveals diverse intrauterine microbiomes in patients suffering with endometrial polyps. Am. J. Transl. Res. 2016; 8: 1581–1592.
4. Benner M., Ferwerda G., Joosten I., van der Molen R.G. How uterine microbiota might be responsible for a receptive, fertile endometrium. Hum. Reprod. Update. 2018; 24: 393–415.
5. Cariati F., D’Argenio V., Tomaiuolo R. The evolving role of genetic tests in reproductive medicine. J. Transl. Med. 2019; 17: 267.
6. El-Hamarneh T., Hey-Cunningham A.J., Berbic M. [et al.] Cellular immune environment in endometrial polyps. Fertil. Steril. 2013; 100: 1364–1372.
7. Verstraelen H., Vilchez-Vargas R., Desimpel F. [et al.] Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J 4. 2016; e1602. 10.7717/peerj.1602
8. Cicinelli E., Matteo M., Trojano G. [et al.] Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception. Am. J. Reprod. Immunol. 2018; 79(1). doi: 10.1111/aji.12782.
9. Puente E., Alonso L., Laganà A.S. [et al.] Chronic endometritis: old problem, novel insights and future challenges. J. Int. J. Fertil. Steril. 2020; 13(4): 250-6.
10. Mitchell C.M., Haick A., Nkwopara E. [et al.] Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol. 2015; 212: 611. e1–9. 10.1016/j.ajog.2014.11.043
11. Song S.D., Acharya K.D., Zhu J.E. [et al.]. Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise mSphere. 2020; 5 (4): e00593–20. 10.1128/mSphere.00593-20
12. Cicinelli E., Resta L., Nicoletti R. [et al.] Detection of chronic endometritis at fluid hysteroscopy. J Minim Invasive Gynecol. 2005; 12 (6): 514–8.
13. Vitagliano A., Saccardi C., Noventa M. [et al.]Effects of chronic endometritis therapy on in vitro fertilization outcome in women with repeated implantation failure: a systematic review and meta-analysis. Fertil Steril. 2018; 110: 103–112. e1.
14. Sfakianoudis K., Simopoulou M., Nikas Y. [et al.] Efficient treatment of chronic endometritis through a novel approach of intrauterine antibiotic infusion: a case series. BMC Womens Health. 2018; 18(1): 197.
15. Franasiak J.M., Werner M.D., Juneau C.R. [et al.]Endometrial microbiome at the time of embryo transfer: Next-generation sequencing of the 16S ribosomal subunit. J. Assist. Reprod. Genet. 2016; 33: 129–136.
16. Moreno I., Garcia-Grau I., Perez-Villaroya D. [et al.] Endometrial microbiota composition is associated with reproductive outcome in infertile patients. Microbiome. 2022; 10(1): 1.
17. Espinoza J., Erez O., Romero R. Preconceptional antibiotic treatment to prevent preterm birth in women with a previous preterm delivery. Am J Obstet Gynecol. 2006; 194 (3): 630–7.
18. Evidence that the endometrial microbiota has an effect on implantation success or failure / I. Moreno, F.M. Codoñer, F. Vilella [et al.] // Am. J. Obstet. Gynecol. – 2016. – Vol.215. – P.684–703.
19. Franasiak J.M., Scott R.T. Jr. Introduction: microbiome in human reproduction. Fertil Steril. 2015; 104:1341–3.
20. Giudice L.C. Challenging dogma: the endometrium has a microbiome with functional consequences! Am J Obstet Gynecol. 2016; 215(6): 682-683.
21. Chen W., Wei K., He X. [et al.] Identification of Uterine Microbiota in Infertile Women Receiving in vitro Fertilization With and Without Chronic Endometritis. Front. Cell Dev. Biol. 2021; 9: 693267.
22. Chen P., Guo Y. [et al.] Interaction Between Chronic Endometritis Caused Endometrial Microbiota Disorder and Endometrial Immune Environment Change in Recurrent Implantation Failure. Front Immunol. 2021; 12: 748447.
23. Kyono K., Hashimoto T., Nagai Y., Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: A single-center pilot study. Reprod. Med. Biol. 2018; 17: 297–306.
24. Miles S.M., Hardy B.L., Merrell D.S. Investigation of the microbiota of the reproductive tract in women undergoing a total hysterectomy and bilateral salpingo-oopherectomy. Fertil Steril. 2017; 107: 813–20.
25. Moreno I., Simon C. Relevance of assessing the uterine microbiota in infertility. Fertil. Steril. 2018; 110: 337–343.
26. Onderdonk A.B., Delaney M.L., Fichorova R.N. The Human Microbiome during Bacterial Vaginosis. Clin Microbiol Rev. 2016; 29(2): 22338.
27. Power M.L., Quaglieri C., Schulkin J. Reproductive Microbiomes: A New Thread in the Microbial Network. Reprod. Sci. 2017; 24: 1482–1492.
28. Campisciano G., Florian F., D’Eustacchio A. [et al.] Subclinical alteration of the cervical-vaginal microbiome in women with idiopathic infertility. J. Cell Physiol. 2017; 232: 1681–1688.
29. Garcia-Grau I., Perez-Villaroya D., Bau D. [et al.] Taxonomical and Functional Assessment of the Endometrial Microbiota in A Context of Recurrent Reproductive Failure: A Case Report. Pathogens. 2019; 8: 205.
30. Takebayashi A., Kimura F., Kishi Y. [et al.] The association between endometriosis and chronic endometritis. PLoS ONE. 2014; 9: e88354.
31. Moreno I., Cicinelli E., Garcia-Grau I. [et al.] The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 2018; 218: 602.e1–16.
32. Chen C., Song X., Wei W. [et al.] The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat. Commun. 2017; 8: 875.
33. Crha I., Ventruba P., Žáková J. [et al.] Uterine microbiome and endometrial receptivity. Ceska Gynekol. 2019; 84(1): 49-54. English. PMID: 31213058.
34. Younes J.A., Lievens E., Hummelen R. [et al.] Women and Their Microbes: The Unexpected Friendship. Trends Microbiol. 2018; 26: 16–32. doi: 10.1016/j.tim.2017.07.008.
Review
For citations:
Polina M.I., Vityazeva I.I., Zakharova P.N., Douglas N.I. Features of the endometrial microbiome of infertile women and its effect on the viability of the "implantation window" phase. Yakut Medical Journal. 2022;(4):23-28. https://doi.org/10.25789/YMJ.2022.80.06
Views:
36
Email this article 