Микробиом опухолей поджелудочной железы
https://doi.org/10.25789/YMJ.2024.88.23
Аннотация
Рак поджелудочной железы (РПЖ) является одним из самых летальных типов злокачественных новообразований с очень низкой выживаемостью (5-7%), которая связана со сложностью его ранней диагностики и агрессивным течением. Прогрессия и метастазирование опухоли завязаны на множестве аспектов, одним из которых является её микробиом. Микробиота участвует в формировании иммунной толерантной среды, что способствует развитию рака, индуцируя процессы ангиогенеза, хеморезистентности, подавления иммунных клеток, инвазии и метастазирования опухоли. Изменения микробного состава опухоли и модуляция иммунной функции в конечном итоге могут повлиять на течение и исход заболевания. Расширение знаний о составе и путях попадания микроорганизмов в такие опухоли, как рак поджелудочной железы, позволит найти факторы, прогнозирующие их поведение и потенциальные таргеты для терапии. Цель обзора: обобщение известных к настоящему времени о составе микробиома и источниках микроорганизмов в опухолях поджелудочной железы.
При поддержке: Работа выполнена в рамках проекта РНФ № 24-25-00460.
Об авторах
М. С. Федорова
ФГБУН Институт молекулярной биологии им. В.А. Энгельгардта РАН
Россия
Россия
Федорова Мария Сергеевна – к.б.н., м.н.с.
Москва
В. С. Павлов
ФГБУН Институт молекулярной биологии им. В.А. Энгельгардта РАН
Россия
Россия
Павлов Владислав Сергеевич – к.б.н., м.н.с.
А. А. Филатова
ФГБУ «Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского» МЗ РФ
Россия
Россия
Филатова Алёна Алексеевна – врач-патологоанатом
Москва
Д. В. Калинин
ФГБУ «Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского» МЗ РФ
Россия
Россия
Калинин Дмитрий Валерьевич – к.м.н., зав. отд.
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Рецензия
Для цитирования:
Федорова М.С., Павлов В.С., Филатова А.А., Калинин Д.В. Микробиом опухолей поджелудочной железы. Якутский медицинский журнал. 2024;(4):98-102. https://doi.org/10.25789/YMJ.2024.88.23
For citation:
Fedorova M.S., Pavlov V.S., Filatova A.A., Kalinin D.V. Microbiome of pancreatic tumors. Yakut Medical Journal. 2024;(4):98-102. (In Russ.) https://doi.org/10.25789/YMJ.2024.88.23
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