Glutathione system state at valproate sodium toxic action
Abstract
Effect of antiepileptic preparation depakin on the lipid peroxide oxidation and glutathione system of rats and possibility of combined use of sodium valproate and antioxidant – immunocal were studied. Depakin injection causes a decreased antioxidant protection and oxidative stress development. Immunocal contributing to the intracellular glutathione synthesis has a protective influence.
About the Authors
L. S. Kolesnichenko
SEE HE ISMU Ministry of Public Health and social development of Russia
Россия
Россия
Kolesnichenko Larisa Stanislavovna – Professor, MD, head of the Chemistry department
664003 Irkutsk, Krasnogo Vosstaniya str., 1, Chemistry department ISMU, Tel.(3952)243825
T. M. Batorova
ISMU
Россия
Россия
Batorova Tatiana Matveevna – post-graduate of the Chemistry department
Tel.89027614869
T. D. Subbotina
ISMU
Россия
Россия
Subbotina Tatiana Dmitrievna – 2-year student of the medical department
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Review
For citations:
Kolesnichenko L.S., Batorova T.M., Subbotina T.D. Glutathione system state at valproate sodium toxic action. Yakut Medical Journal. 2011;(4):33-35.
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