Glutathione system state at valproate sodium toxic action
Abstract
Effect of antiepileptic preparation depakin on the lipid peroxide oxidation and glutathione system of rats and possibility of combined use of sodium valproate and antioxidant – immunocal were studied. Depakin injection causes a decreased antioxidant protection and oxidative stress development. Immunocal contributing to the intracellular glutathione synthesis has a protective influence.
About the Authors
L. S. Kolesnichenko
SEE HE ISMU Ministry of Public Health and social development of Russia
Россия
Россия
Kolesnichenko Larisa Stanislavovna – Professor, MD, head of the Chemistry department
664003 Irkutsk, Krasnogo Vosstaniya str., 1, Chemistry department ISMU, Tel.(3952)243825
T. M. Batorova
ISMU
Россия
Россия
Batorova Tatiana Matveevna – post-graduate of the Chemistry department
Tel.89027614869
T. D. Subbotina
ISMU
Россия
Россия
Subbotina Tatiana Dmitrievna – 2-year student of the medical department
References
1. Kulinsky V.I. The glutathione system I. Synthesis, transport, glutathione transferase, glutathione peroxidase / V.I. Kulinsky, L.S. Kolesnichenko // Biochemistry, Suppl. Series B: Biomed. Chem. – 2009. - № 3. – P. 255-277.
2. Kulinsky V.I. The glutathione system II. Other enzymes, thiol-disulfide metabolism, inflammation and immunity, functions / V.I. Kulinsky, L.S. Kolesnichenko // Ibid. – 2009. –№ 4. – P. 365-379.
3. Oxidative stress. Prooxidants and antioxidants / E.B. Menschikova, V.Z. Lankin, N.K. Zenkov [et al.] // M.: MAIK. – 2006. –556 p.
4. Anderson M.E. Enzymatic and chemical methods for the determination of glutathione. - N.Y., 1989. – Pt.A. – P. 339-366.
5. Assay using brain homogenate for measuring the antioxidant activity of biological fluids / J. Stocks, J.M. Gutteridge, R.J. [et al.]// Clin. Sci. Mol. Med. – 1974. – Vol.47, № 3. – P. 215-222.
6. Effects of valproate, carbamazepine, and levetiracetam on the antioxidant and oxidant systems in epileptic patients and their clinical importance /A.O. Varoglu, A. Yildirim, R. Aygul [et al.] // Clin Neuropharmacol. – 2010.-May, 33(3). – P. 155-7.
7. Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity / T.K. Kiang, X.W. Teng, J. Surendradoss [et al.] // Toxicol Appl Pharmacol. – 2011.- May 1, 252(3). – P. 318-24.
8. Lackmann G.M. Valproic-Acid-Induced Thrombocytopenia and Hepatotoxicity: Discontinuation of Treatment / G.M. Lackmann // Pharmacology. – 2004. – №2. – P. 57-58.
9. Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid/ E. Peker, S. Oktar, M. Ari [et al.] – 2009.- Nov 10;1297:194-7;. Epub 2009. - Aug 21.
10. The effect of antiepileptic drugs on mitochondrial activity: a pilot study / I. Berger, I. Segal, D. Shmueli [et al.] // J Child Neurol.- 2010.- May;25(5):541-5.
11. Valproic Acid–induced Hepatopathy: Nine New Fatalities in Germany from 1994 to 2003 / Stephan A. Koenig [et al.]– 2006. – Vol.47, Issue12. – P. 2027–2031.
Review
For citations:
Kolesnichenko L.S., Batorova T.M., Subbotina T.D. Glutathione system state at valproate sodium toxic action. Yakut Medical Journal. 2011;(4):33-35.
Views:
67
JATS XML
Email this article 