Cytokines and Intrathecal Synthesis of Oligoclonal IgG in Viliuisk Encephalomyelitis and Multiple Sclerosis Patients
Abstract
In work results of interleukin-6,-18 and interferon - γ (INFγ) investigation in blood serum and liquor of patients with Viliuisk encephalomyelitis (VE) and multiple sclerosis (MS) and other neurologic diseases are presented. Statistically significant distinctions in level of interleukin-18 (IL-18) and INFγ in liquor of VE and MS patients are revealed. It is shown that VE patients are characterized by IL-18 raised level in cerebrospinal fluid (CSF), and MS patients - INFγ in CSF and blood serum. The association of INFγ raised level in liquor with revealing intrathecal synthesis IgG in MS patients is ascertained.
About the Authors
T. M. Sivtseva
Federal State Scientifically Institution “Institute of Health”
Russian Federation
Russian Federation
Sivtseva Tatyana Mikhailovna – Ph.D., laboratory of genetic research
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
R. I. Chemezova
Federal State Scientifically Institution “Institute of Health”
Russian Federation
Russian Federation
Chemezova Rita Ivanovna – head of clinical diagnostic laboratory
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
V. A. Vladimirtsev
Federal State Scientifically Institution “Institute of Health”
Russian Federation
Russian Federation
Vladimirtsev Vsevolod Afanasevich – Ph.D., department of viliuisk encephalomyelitis investigation
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
R. S. Nikitin
Federal State Scientifically Institution “Institute of Health”
Russian Federation
Russian Federation
Nikitina Raisa Semenovna – head of hospital of Institute of Health
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
A. P. Danilova
Federal State Scientifically Institution “Institute of Health”
Russian Federation
Russian Federation
Danilova Albina Prokopevna - hospital of Institute of Health
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
T. E. Popova
Federal State Scientifically Institution “Institute of Health”;
Medical Institute of North-Eastern Federal University;
Center of Multiple sclerosis in Republic Sakha (Yakutia)
Russian Federation
Russian Federation
Popova Tatyana Egorovna – Ph.D.;
scientific consultantphone: (411-2) 432318
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
L. T. Okoneshnikova
Federal State Scientifically Institution “Institute of Health”;
Republic hospital #2;
Center of Multiple sclerosis in Republic Sakha (Yakutia)
Russian Federation
Russian Federation
Okoneshnikova Ludmila Timofeevna – head of Neurological Department;
Head
phone: (411-2) 432318
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
V. L. Осаковский
Federal State Scientifically Institution “Institute of Health”
Russian Federation
Russian Federation
Osakovsky Vladimir Leonidovich – PhD, head of laboratory of genetic research
Bldg C2, Sergelyakhskaya Rd, 677010 Yakutsk, phone: (411-2) 36-15-36
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Review
For citations:
Sivtseva T.M., Chemezova R.I., Vladimirtsev V.A., Nikitin R.S., Danilova A.P., Popova T.E., Okoneshnikova L.T., V.L. Cytokines and Intrathecal Synthesis of Oligoclonal IgG in Viliuisk Encephalomyelitis and Multiple Sclerosis Patients. Yakut Medical Journal. 2011;(4):27-30.
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