Association of polymorphic variant rs1800849 of the UCP3 gene with deficit and excess of body weight in the Yakut population
A. A. Nikanorova,
N. A. Barashkov,
V. G. Pshennikova,
N. N. Gotovtsev,
G. P. Romanov,
A. V. Solovyev,
S. A. Fedorova https://doi.org/10.25789/YMJ.2022.80.04
Abstract
Genetic predisposition to obesity may play an important role in its etiology along with environmental influences. One of such potential therapeutic targets is uncoupling protein 3 (UCP3), is encoded by the UCP3 gene. The main functions of UCP3 are considered to be proton transport in the presence of fatty acids, and a protective function, UCP3 can inhibit the actions of reactive oxygen species in mitochondria. The purpose of this study is to search for the association of polymorphism rs1800849 of the UCP3 gene with body mass index (BMI) in the Yakut population. No significant differences in the distribution of alleles were found (χ2 = 0.72; p = 0.397), so the frequency of allele (T) was 53%, and allele (C) was 47%. In females from the control group, it was founding that the heterozygous genotype was more common (p = 0.04) than in people with underweight. In males with overweight, the allele (C) is more common (p = 0.001), compared with the control group. The distribution of alleles of the rs1800849 polymorphism of the UCP3 gene showed that in individuals with underweight (both females and males), the frequency of the allele (T) was significantly higher than the frequency of the allele (C) (p = 0.001). Allele (C) was more common in overweight males (p = 0.001), no such differences were found in females (p > 0.05). The article discusses the probable relationship of the distribution of rs1800849 alleles of the UCP3 gene with the rate of basal metabolism affecting body weight, which is probably due to adaptation to a cold climate.
About the Authors
A. A. Nikanorova
Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Nikanorova Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics
N. A. Barashkov
Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Barashkov Nikolay Alekseevich – PhD in Biology, Head of laboratory of Molecular genetics
V. G. Pshennikova
Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Pshennikova Vera Gennadievna – PhD in Biology, Head of laboratory of Populational Genetics
N. N. Gotovtsev
Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Gotovtsev Nyurgun Naumovich – scientific researcher, Laboratory of Molecular Genetics
G. P. Romanov
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Romanov Georgii Prokopievich – Researcher, Research Laboratory of Molecular Biology, Institute of Natural Sciences
A. V. Solovyev
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Solovyov Aisen Vasilyevich – PhD in Biology, Senior Researcher, Research Laboratory of Molecular Biology
S. A. Fedorova
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Fedorova Sardana Arkadievna – Doctor of Biology, Head of the Research Laboratory of Molecular Biology
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Review
For citations:
Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Gotovtsev N.N., Romanov G.P., Solovyev A.V., Fedorova S.A. Association of polymorphic variant rs1800849 of the UCP3 gene with deficit and excess of body weight in the Yakut population. Yakut Medical Journal. 2022;(4):16-19. https://doi.org/10.25789/YMJ.2022.80.04
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