Ассоциация полиморфного варианта rs1800849 гена UCP3 с дефицитом и избытком массы тела в популяции якутов

Целью данного исследования является поиск ассоциации полиморфизма rs1800849 гена UCP3 c индексом массы тела в популяции якутов. Распределение аллелей полиморфизма rs1800849 гена UCP3 показало, что у лиц с дефицитом веса (как у женщин, так и у мужчин) частота аллеля (Т) была значительно выше, чем частота аллеля (С). У мужчин с избытком веса чаще встречался аллель (С), у женщин таких различий не было обнаружено. В статье обсуждается вероятная взаимосвязь распределения аллелей rs1800849 гена UCP3 со скоростью базального метаболизма, влияющего на массу тела, что, вероятно, обусловлено адаптацией к холодному климату.

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