ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.80.04ymj-215Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАссоциация полиморфного варианта rs1800849 гена UCP3 с дефицитом и избытком массы тела в популяции якутовAssociation of polymorphic variant rs1800849 of the UCP3 gene with deficit and excess of body weight in the Yakut populationhttps://orcid.org/0000-0002-7129-6633НиканороваА. А.NikanorovaA. A.

Никанорова Алена Афанасьевна – м.н.с.,

Nikanorova Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics

nikanorova.alena@mail.ruhttps://orcid.org/0000-0002-6984-7934БарашковН. А.BarashkovN. A.

БарашкоВ Николай Алексеевич – к.б.н., в.н.с.-руковод. лаб.

Barashkov Nikolay Alekseevich – PhD in Biology, Head of laboratory of Molecular genetics

barashkov2004@mail.ruhttps://orcid.org/0000-0001-6866-9462ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – к.б.н., в.н.с.руковод. лаб.

Pshennikova Vera Gennadievna – PhD in Biology, Head of laboratory of Populational Genetics

pshennikovavera@mail.ruhttps://orcid.org/0000-0002-4710-1592ГотовцевН. Н.GotovtsevN. N.

Готовцев Ньургун Наумович – н.с.

Gotovtsev Nyurgun Naumovich – scientific researcher, Laboratory of Molecular Genetics

donzcrew@mail.ruhttps://orcid.org/0000-0002-2936-5818РомановГ. П.RomanovG. P.

Романов Георгий Прокопьевич – м.н.с., Институт естественных наук 

Romanov Georgii Prokopievich – Researcher, Research Laboratory of Molecular Biology, Institute of Natural Sciences

gpromanov@gmail.comhttps://orcid.org/0000-0003-0914-3609СоловьевА. В.SolovyevA. V.

Соловьев Айсен Васильевич – к.б.н., с.н.с., Институт естественных наук 

Solovyov Aisen Vasilyevich   – PhD in Biology, Senior Researcher, Research Laboratory of Molecular Biology

nelloann@mail.ruhttps://orcid.org/0000-0002-6952-3868ФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., гл.н.с., Институт естественных наук 

Fedorova Sardana Arkadievna – Doctor of Biology, Head of the Research Laboratory of Molecular Biology

sardaanafedorova@mail.ruЯкутский научный центр комплексных медицинских проблемРоссияYakut Science Center of Complex Medical ProblemsRussian FederationСВФУ им. М.К. АммосоваРоссияM.K. Ammosov North-Eastern Federal UniversityRussian Federation202205022025041619Copyright © Никанорова А.А., Барашков Н.А., Пшенникова В.Г., Готовцев Н.Н., Романов Г.П., Соловьев А.В., Федорова С.А., 20252025Никанорова А.А., Барашков Н.А., Пшенникова В.Г., Готовцев Н.Н., Романов Г.П., Соловьев А.В., Федорова С.А.Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Gotovtsev N.N., Romanov G.P., Solovyev A.V., Fedorova S.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/215

Целью данного исследования является поиск ассоциации полиморфизма rs1800849 гена UCP3 c индексом массы тела в популяции якутов. Распределение аллелей полиморфизма rs1800849 гена UCP3 показало, что у лиц с дефицитом веса (как у женщин, так и у мужчин) частота аллеля (Т) была значительно выше, чем частота аллеля (С). У мужчин с избытком веса чаще встречался аллель (С), у женщин таких различий не было обнаружено. В статье обсуждается вероятная взаимосвязь распределения аллелей rs1800849 гена UCP3 со скоростью базального метаболизма, влияющего на массу тела, что, вероятно, обусловлено адаптацией к холодному климату.

Genetic predisposition to obesity may play an important role in its etiology along with environmental influences. One of such potential therapeutic targets is uncoupling protein 3 (UCP3), is encoded by the UCP3 gene. The main functions of UCP3 are considered to be proton transport in the presence of fatty acids, and a protective function, UCP3 can inhibit the actions of reactive oxygen species in mitochondria. The purpose of this study is to search for the association of polymorphism rs1800849 of the UCP3 gene with body mass index (BMI) in the Yakut population. No significant differences in the distribution of alleles were found (χ2 = 0.72; p = 0.397), so the frequency of allele (T) was 53%, and allele (C) was 47%. In females from the control group, it was founding that the heterozygous genotype was more common (p = 0.04) than in people with underweight. In males with overweight, the allele (C) is more common (p = 0.001), compared with the control group. The distribution of alleles of the rs1800849 polymorphism of the UCP3 gene showed that in individuals with underweight (both females and males), the frequency of the allele (T) was significantly higher than the frequency of the allele (C) (p = 0.001). Allele (C) was more common in overweight males (p = 0.001), no such differences were found in females (p > 0.05). The article discusses the probable relationship of the distribution of rs1800849 alleles of the UCP3 gene with the rate of basal metabolism affecting body weight, which is probably due to adaptation to a cold climate.

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The authors declare that there are no conflicts of interest present.