The relationship of lipid profile and blood pressure in men in the European North of Russia

The paper analyzes the relationship of traditional lipid indicators and lipid indices with the level of blood pressure in men living in the European North of Russia. In apparently healthy middle-aged men, normal high blood pressure, abdominal pre-obesity, and compliance of traditional lipid indicators with reference values were revealed. At the same time, a number of lipid indices (atherogenicity coefficient (AC), the ratio of total cholesterol (TC) to high-density lipoprotein cholesterol (HDL-C), atherogenic plasma index (AIP), triglyceride/HDL-C ratio and lipid accumulation index (LAP)) appeared to be elevated.

Correlation analysis revealed the linear relationship of systolic pressure in the brachial artery with the content of Apo A-1, Apo B, TC, low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk (CVR); diastolic pressure with TC, CVR and the waist-hip circumference ratio; heart rate index with waist and hip circumferences and body mass index. More number and greater strength of significant correlations were found between indicators of central hemodynamics and lipid profile. The relationships between age and length of living in the North with peripheral and central hemodynamic parameters turned out to be obvius.

Thus, male northern residents with normal high blood pressure have abdominal pre-obesity, normolipidemia but elevated lipid indices. Apparently, lipid indices are of greater prognostic significance and may be more sensitive predictors of the risk of arterial hypertension at the normal level of traditional lipid profile indicators.

Correlation analysis revealed the linear relationship of systolic pressure in the brachial artery with the content of Apo A-1, Apo B, TC, low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk (CVR); diastolic pressure with TC, CVR and the waist-hip circumference ratio; heart rate index with waist and hip circumferences and body mass index.

More number and greater strength of significant correlations were found between indicators of central hemodynamics and lipid profile.

The interrelations between lipid parameters and pressure level were revealed: a) positive correlation of AC with peripheral systolic and diastolic pressure, systolic pressure in the aorta, diastolic and pulse pressure, b) TC-non-HDL with systolic and diastolic pressure in the aorta, c) negative correlation of LAP with peripheral pulse pressure.

These correlations indicate that in Arctic conditions, the presence of normolipidemia and pre-obesity may be a prerequisite for the formation of normal high pressure.

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