Genetics of patients with multiple sclerosis, living in terrain of Yakutia
Abstract
Results of genetic research on row of gene-candidates determining predisposition to multiple sclerosis disease are given. For the first time it is shown that disease has reliable association with reception gene CD40 and cytokine gene TNF-α.
About the Authors
V. L. Osakovsky
FSNO “Institute of health”
Russian Federation
Russian Federation
M. L. Filippenko
Yakutsk Institute of Chemical Biology and Fundamental Medicine SD RAS
Russian Federation
Russian Federation
Novosibirsk
T. M. Sivtseva
FSNO “Institute of health”
Russian Federation
Russian Federation
F. A. Platonov
FSNO “Institute of health”
Russian Federation
Russian Federation
References
1. Cerebrospinal fluid IgG profiles and multiple sclerosis in Japan / F. Moriwaka, K. Sugiyama [et al.] // Acta Neurol.Scand. 1993, 88;178-183.
2. Tumor necrosis factor –a mediates lipopolysaccaharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present / R Ramenaden, J. Peng [et al.] // The journal of neuroscience. – 2008, 28(20);5321-5330.
3. CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system / J. Huang, W. Gong [et al.] // Cellular&Molecular Immunology. – 2006; 3(3): 163-169.
4. Ponomarenko N. Autoantibodies to myelin basic protein catalyze site- specific degradation of their antigen / N. Ponomarenko, O. Durova, I. Vorobiev [et al.] // Proc.Natl.Acad. Sci USA, 2006;103(2);281-286.
5. Chabot S. / Mechanism of IL-10 pro-duction in human microglia-T cell interaction / S. Chabot, G. Williams, M. Hamilton [et al.] // Journal of immunology, 1999: 162; 6819-6828.
6. Lim S.Y., C. Constatinescu / TNFα: Paradigm of paradox and complexity in multiple sclerosis and its animal models / S.Y. Lim, C. Constatinescu // The open autoimmunity journal, 2010; 2: 160-170.
7. Thompson E.J., Keir G. / Laboratory investigation of cerebrospinal fluid proteins / E.J. Thompson, G. Keir // Ann.Clim. Biochem. - 1990; 27;425-435.
Review
For citations:
Osakovsky V.L., Filippenko M.L., Sivtseva T.M., Platonov F.A. Genetics of patients with multiple sclerosis, living in terrain of Yakutia. Yakut Medical Journal. 2011;(2):38-39.
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