Genetics of patients with multiple sclerosis, living in terrain of Yakutia
Abstract
Results of genetic research on row of gene-candidates determining predisposition to multiple sclerosis disease are given. For the first time it is shown that disease has reliable association with reception gene CD40 and cytokine gene TNF-α.
About the Authors
V. L. OsakovskyРоссия
M. L. Filippenko
Россия
Novosibirsk
T. M. Sivtseva
Россия
F. A. Platonov
Россия
References
1. Cerebrospinal fluid IgG profiles and multiple sclerosis in Japan / F. Moriwaka, K. Sugiyama [et al.] // Acta Neurol.Scand. 1993, 88;178-183.
2. Tumor necrosis factor –a mediates lipopolysaccaharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present / R Ramenaden, J. Peng [et al.] // The journal of neuroscience. – 2008, 28(20);5321-5330.
3. CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system / J. Huang, W. Gong [et al.] // Cellular&Molecular Immunology. – 2006; 3(3): 163-169.
4. Ponomarenko N. Autoantibodies to myelin basic protein catalyze site- specific degradation of their antigen / N. Ponomarenko, O. Durova, I. Vorobiev [et al.] // Proc.Natl.Acad. Sci USA, 2006;103(2);281-286.
5. Chabot S. / Mechanism of IL-10 pro-duction in human microglia-T cell interaction / S. Chabot, G. Williams, M. Hamilton [et al.] // Journal of immunology, 1999: 162; 6819-6828.
6. Lim S.Y., C. Constatinescu / TNFα: Paradigm of paradox and complexity in multiple sclerosis and its animal models / S.Y. Lim, C. Constatinescu // The open autoimmunity journal, 2010; 2: 160-170.
7. Thompson E.J., Keir G. / Laboratory investigation of cerebrospinal fluid proteins / E.J. Thompson, G. Keir // Ann.Clim. Biochem. - 1990; 27;425-435.
Review
For citations:
Osakovsky V.L., Filippenko M.L., Sivtseva T.M., Platonov F.A. Genetics of patients with multiple sclerosis, living in terrain of Yakutia. Yakut Medical Journal. 2011;(2):38-39.
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