Content of elements of calcium and phosphorus in blood plasma under the influence of ß- cyclodextrin derivatives
Abstract
The maintenance of the element maintenance of calcium and phosphorus in plasma of blood at laboratory animals is investigated at application of the new derivative connections which are being clathrate and conjugate of β-cyclodextrin with acid paraaminobenzoic were used. Positive dynamics of the maintenance of defined elements under influence of the synthesized substances is revealed. The most positive tendency is found out in the skilled group received conjugate of β-cyclodextrin with acid paraaminobenzoic.
Supporting agencies: Work is executed at financial support of the Russian Federal Property Fund (the grant № 08- 03-00374).
About the Authors
A. A. Sergievich
ГОУ ВПО Амурская ГМА Росздрава
Россия
Россия
M. K. Grachev
ГОУ ВПО Московский ГПУ Министерства образования и науки РФ
Россия
Россия
G. I. Kurochkina
ГОУ ВПО Московский ГПУ Министерства образования и науки РФ
Россия
Россия
T. A. Batalova
ГОУ ВПО Амурская ГМА Росздрава
Россия
Россия
M. L. Plastinin
ГОУ ВПО Амурская ГМА Росздрава
Россия
Россия
References
1. Batalova T.A. Anti-inflammatory activity of new synthetic connection of b-cyclodextrin and acetylsalicylic acids / T.A. Batalova, V.A. Dorovskih, M.L. Plastinin // Far East Medical Journal. - 2008. - № 2. - P. 105-107.
2. Glants S. Medico-biological statistics / S. Glants. - М.: “Praktika”, 1999. - 459 p.
3. Karpushina O.V. Age dynamics of a calciumphosphorus exchange and natural resistance at application of paraaminobenzoic acid in conditions of Priamur’e: aftoref. diss. … cand. biol. sci. / O.V. Karpushina. - Blagoveshchensk, 2004. - 22 p.
4. Leporsky N.I. To the analysis of the Novocain general action / N.I. Leporsky, T.T. Karakulina // Works of Naval. Acad.- 1952.- V. 39. - P. 50-51.
5. Some aspects of phosphor-calcium metabolism regulation: a role of kidneys / O.V. Chumakova, N.N. Kartamysheva, G.V. Kuznetsova [et al.] // Medical scientific and teaching-methods journal. - 2002. - № 11. - Р. 157-173.
6. Paraaminobenzoic acid / under ed. of M.I. Smirnov. - М.:, 1974. - 460 p.
7. Stroeva O.G. Endogen connections in morphogenesis and regenerative processes - integrating and regulatory systems: the theory and practice / O.G. Stroeva // Biological properties of paraaminobenzoic acid. 2000.- V. 31, № 4. - P. 259-260.
8. Davis M.E. Cyclodexrin-based pharmaceutics: Past, Present and Future / M.E. Davis, M.E. Brewster // Natural Rev. Drug Discovery. - 2004. - V.3. - P. 1023-1035.
9. Minami K. Colon-specific drug delivery based in a cyclodextrin prodrug release behavior of biphenylylacetic asid from its cyclodextrin conjugates in ratintestinal tracts after oral administration / K. Minami, F. Hirayama, Uekama // J. Pharm. Sci. - 1998. - V.87, № 6. - P. 715-720.
10. Uekama K. 6a-O-[(4-Biphenil)acetil] – α-,-β-, and –γ-cyclodextrins and 6a-deoxy – 6a-[[4-biphenil)acetyl]amino]-α-, -β- and -γ-cyclodextrins: potential prodrugs for colon-specific delivery / К. Uekama, К. Minami, F. Hirayama // J. Med. Chem. – 1997. - V.40, № 17. - P. 2755-2761.
11. Uekama K. Cyclodextrin drug carrier systems / K. Uekama, F. Hirayama, T. Irie // Chem. Rev. – 1998. - V. 98, N5. - P. 2045-2076.
12. Yano H. Colon-specific delivery of prednisolone-appended α-cyclodextrin conjugate: alleviation of systemic side effect after oral administration / H. Yano, F. Hirayama, M. Kamada // J. Cont. Rel. - 2002. - V.79., № 3. - P.103-112.
13. Yung-Jato L.L. Liquid chromatographic measurement of p-aminobenzoic acid and its metabolites in serum / L.L. Yung-Jato, P.R. Durie,S.J. Soldin // Clin. Chem. 1998. – V. 11, № 34. - Р. 2235-2238.
Review
For citations:
Sergievich A.A., Grachev M.K., Kurochkina G.I., Batalova T.A., Plastinin M.L. Content of elements of calcium and phosphorus in blood plasma under the influence of ß- cyclodextrin derivatives. Yakut Medical Journal. 2011;(1):101-103.
Views:
68
JATS XML
Email this article 