Distinctive features in morphogenesis of pulmonary tuberculomas in non-indigenous patients of the Extreme North

Abstract

For a decade (1997-2007), morphogenesis features of different types of tuberculomas were studied in 125 non-aboriginal patients living in the environmental conditions of the Extreme North. The study showed that morphogenesis of tuberculoma in non-aboriginal patients started more often as a result of specific alterations following lymphohematogenous tuberculosis (72.9 ± 3.2%; р < 0.01). Interestingly, tuberculous alterations in the lungs developed amid unaltered lung tissue. As a rule, formation of tuberculomas in patients from non-aboriginal population is not associated with the development of marked fibrosis of lung tissue. These distinctive features of tuberculoma formation were determined by predomination of the processes of healing and alveolar epithelium renewal over inflammatory changes, thanks to which a better repair of the structure of lung parenchyma could be attained in the end.