Association of polymorphic markers of adiponectine gene with diabetic retinopathy at type 2 diabetes mellitus in the Yakuts
Abstract
Revealed genotype *H/*H of polymorphyc variant Y111H(ADIPOQ) of adiponectine gene is a marker of high risk of diabetic retinopathy in type2 diabetes mellitus for ethnic group of the Yakuts.
The obtained results will assist duly prognosis and /or revealing of risk group of diabetic retinopathy among the Yakuts and will help to define the treatment tactics for patients predisposed to diabetic retinopathy with the use of individual complex of prophylactic and treatment activities.
About the Authors
L. L. AlekseevaRussian Federation
P. M. Ignatyev
Russian Federation
V. L. Osakovsky
Russian Federation
F. A. Platonov
Russian Federation
H. Sambuugin
United States
L. G. Goldfarb
United States
References
1. Алексеева Л.Л. Клинические особенности развития сахарного диабета 2 типа у якутов / Л.Л. Алексеева, П.М.Игнатьев, Ф.А.Платонов, В.И.Лазаренко //Якутский медицинский журнал.-2010.- №1. – С.7-10.
2. Дедов И.И. Жировая ткань как эндокринный орган / И.И. Дедов, Г.А. Мельниченко //www.endocrincenter.ru/Atc1106.html.
3. Нестеров А.П. Диабетическая ретинопатия / А.П. Нестеров // Российский медицинский журнал.-2000.- №1.- с.
4. Скоробогатова Е.С. Инвалидность по зрению вследствие сахарного диабета / Е.С. Скоробогатова.-М.:Медицина, 2003.-208.
5. Сыдыкова Л.А. Дислипидемия у пожилых людей, страдающих сахарным диабетом 2 типа и ИБС в условиях Республики Саха (Якутия) / Л.А. Сыдыкова, В.И. Гагарин // Мат-лы II Сибирской конф., посв. 50-летию эндокринологич. службы Красноярского края.- Красноярск, 2003.- С. 37-38.
6. Федорова С.А. Генетические портреты народов Республики Саха (Якутии): анализ митохондриальной ДНК и Y-хромосомы / С.А. Федорова .- Якутск: Изд-во ЯНЦ СО РАН. - 2008. -235 с.
7. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway / N. Ouchi [et al.] // Circulation. – 2000. – V. 102. – P. 1296-1301.
8. Association of the human adiponectin gene and insulin resistance / E. Filippi [et al.]. Europ. J. Hum. Genet, 2004. 12: 199-205.
9. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes / M. Stumvoll [et al.] // Diabetes. - 2002 51:37–41.
10. Bishop T. Analysis of multifactorial disease / T. Bishop, P. Sham // BIOS Ltd. - 2000. – P.345.
11. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys / K. Hotta [et al.] // Diabetes. – 2001. – V. 50. – P. 1126 –1133.
12. Diabetes mellitus. General information. Diabetes statistics // NIH publications. – 1998. – P. 96-3926.
13. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population / K. Hara [et al.] // Diabetes. - 2002. 51:536–540.
14. Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians / F. Gu. Harvest // Diabetes. - 2004. 53 (Suppl. 1):S31–S35.
15. Kadowaki T. Adiponectin and Adiponectin Receptors / T. Kadowaki, T. Yamauchi // Endocrine Reviews. – 2005. – V. 26. – P. 439–451.
16. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin / N. Ouchi [et al.] // Circulation. – 1999. – V. 100. – P. 2473-2476.
17. Reaven G.M. Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease / G.M. Reaven // J Clin Endocrinol Metab. - 2003;88:2399-2403.
18. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians / Vasseur F. [et al.] // Hum. Molec. Genet. – 2002. 11: 2607-2614.
19. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / A. H. Berg [et al.] // Nat. Med. – 2001. – V.17. – P.947–953.
Review
For citations:
Alekseeva L.L., Ignatyev P.M., Osakovsky V.L., Platonov F.A., Sambuugin H., Goldfarb L.G. Association of polymorphic markers of adiponectine gene with diabetic retinopathy at type 2 diabetes mellitus in the Yakuts. Yakut Medical Journal. 2011;(1):37-40.








