Effects of stress in late prenatal ontogenesis on the development indicators of the brain, adrenals and gonads of 40-days age rats
Abstract
Studying of stress effect in the late prenatal ontogeny on morphometrical indexes of development of brain, adrenals and gonads of rats at 40- day age, subjected to stress influence by immobilization in the conditions of the high illumination in the narrow plastic cases limiting their motility is made.
Changes of both gravimetric and morphometric indexes of neocortex and hippocampus, and also adrenals and gonads at posterity of female rat subjected to stress influence are established.
About the Authors
I. V. Nikolaeva
МИ СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
D. S. Beloljubskaja
МИ СВФУ
Russian Federation
Russian Federation
V. A. Argunov
МИ СВФУ
Russian Federation
Russian Federation
References
1. Vedyaev F.P. Stress and organism / F.P. Vedyaev // RAMS Bulletin. – 1992. – Issue 5. P.17 – 21.
2. Gerschtein L.M. Morphochemical features of rats hippocampus neurons distinguishing by behavior / L.M. Gerschtein, I.M. Korneva, V.I. Rakhmanova // Bulletin of experimental biology and medicine. – 2007. – Vol. 144, Issue 12. – P. 696-698.
3. Kirillov O.I. Sexual dimorphism of rats adrenals postnatal growth / The Problems of endocrinology. – 1998. – Issue 5. – P. 45-46.
4. Mitskevich M.S. Hormone regulations in animals ontogeny. / M.S. Mitskevich // M., 1978. – P. 224.
5. Ordyan N.E. Level of uneasiness and neurosteroids synthesis in the brain of prenatal stressed men rats / Russian physiological journal. – 2002. – Vol. 88, Issue 7. – P. 900-906.
6. Otellin V.A. Damaging influences in critical periods of prenatal ontogeny as a factor modifying structural brain development and behavior reactions after the birth / V.A. Otellin, D.E. Korzhevskiy, E.G. Gilerovich etc. // RAMS Bulletin. – 2002. – Issue 12. – P. 32-35.
7. Pavlova I.G. The influence of changing hormone background on neurons development in the system “mother – fetus” / I.G. Pavlova // Morphology. – 1992. – Vol. 102, Issue 4. – P. 25-33.
8. Pshennikova M.G. Phenomenon of the stress. Emotional stress and its role in pathology (continuing) / M.G. Pshennikova // Pathologic physiology and experimental therapy. – 2001. – Issue 3. – P. 20-26.
9. Sapozhnikov Y.A. Mathematical and experimental analysis of optimization’s opportunities of rats’ higher nervous activity (behavior) evaluation. / Y.A. Sapozhnikov, Y.I. Feldsherov, B.Y. Ryzhavskiy // Far Eastern medical journal. – 2002. – Issue 4. – P. 25-28.
10. Bozzo A. Chronic stress effects on the apoptotic index of the adrenal cortex of pregnant rats / A. Bozzo, S.A. Sonez, M.T. Mugnaini [et al.] // Biocell. – 2006. - № 30 (3). – P. 439-445.
11. Kempna P. Adrenal gland development and defects / P. Kempna, C.E. Fluck // Best Pract Res Clin Endocrinol Metab. - 2008. - № 22 (1). – P. 77-93.
12. Masilamoni J.G. The neuroprotective role of melatonin against amyloid beta peptide injected mice / J.G. Masilamoni, E.P. Jesudason, S. Dhandayuthapani [et al.] // Free Radic Res. – 2008. - № 42 (7). - P. 661-673.
13. McEwen B.S. Physiology and neurobiology of stress and adaptation: central role of the brain / B.S. McEwen // Physiol Rev. – 2007. – № 87 (3). – P. 873-904.
Review
For citations:
Nikolaeva I.V., Beloljubskaja D.S., Argunov V.A. Effects of stress in late prenatal ontogenesis on the development indicators of the brain, adrenals and gonads of 40-days age rats. Yakut Medical Journal. 2011;(1):12-14.
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