Protein markers of negative effects in children under the influence of natural cold
https://doi.org/10.25789/YMJ.2023.81.21
Abstract
Currently, a promising study is the identification of changes in the level of expressed proteins (omic markers) in the body under the influence of adverse factors, including climatic ones, reflecting the destabilization of homeostasis. The purpose of the study was to identify protein markers of negative effects in children living under the influence of adverse factors of the subarctic climate.
Materials and methods. A study of the proteomic profile of the blood plasma of children was carried out; statistical evaluation of the values of the relative volume of identified protein spots; establishing and evaluating a probable relationship between the change in the relative volume of identified protein spots and the impact of adverse factors of the subarctic climate.
Results and discussion. Under the influence of adverse factors of the subarctic climate in children of the observation group, relative to the indicators in children of the control group, there was a significant change in the volume of proteins (prothrombin, vitronectin, hemoglobin beta subunit, apolipoproteins A1, C-II and C-III, amyloid proteins A-1 and A- 2, P2Y purinoreceptor 12, transthyretin), the expression or decrease in production of which can cause a violation of the cascade of reactions of the blood coagulation system, a change in the development of mature forms of erythrocytes, a violation of the regulation of reverse cholesterol transport, and damage to endothelial cells.
Conclusion. The study made it possible to establish a relationship between the impact of adverse factors of the subarctic climate and the expression of proteins (apolipoprotein C-III, transthyretin, prothrombin, vitronectin, and hemoglobin β-subunit) identified in the blood plasma of children exposed to this effect. The established omic markers make it possible to predict the development of negative effects in the form of impaired hemostasis mechanisms, intracellular cholesterol esterification, insufficient oxygen supply to tissues, and endothelial dysfunction. The obtained results should be used for predicting, early detection and prevention of the development of possible diseases of the cardiovascular system, blood and hematopoietic organs associated with prolonged exposure to natural cold.
About the Authors
N. V. Zaitseva
FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
Russian Federation
Zaitseva Nina Vladimirovna – RAS Academician, MD, Professor, Scientific Director
Perm
М. А. Zemlyanova
FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
Russian Federation
Zemlyanova Marina Aleksandrovna – MD, Chief Researcher, Head of the Department
Perm
Yu. V. Koldibekova
FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
Russian Federation
Koldibekova Yuliya Vyacheslavovna – PhD, Senior Researcher, Head of the Laboratory
Perm
Е. V. Peskova
FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
Russian Federation
Peskova Ekaterina Vladimirovna – junior researcher
Perm
N. I. Bulatova
FBSI Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Russian Federation
Russian Federation
Bulatova Nataliya Ivanovna – researcher
Perm
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Review
For citations:
Zaitseva N.V., Zemlyanova М.А., Koldibekova Yu.V., Peskova Е.V., Bulatova N.I. Protein markers of negative effects in children under the influence of natural cold. Yakut Medical Journal. 2023;(1):83-87. https://doi.org/10.25789/YMJ.2023.81.21
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