Genetic characteristics and antigenic properties of phospholipase α from outer membrane yersinia pseudotuberculosis
Abstract
The analysis of gene polymorphism of Y. pseudotuberculosis membrane-associated phospholipase A was carried out. The high conservation of this enzyme at the nucleotide and amino acid levels was revealed. Recombinant phospholipase A expressed in E. coli cells was used as an antigen to detect specific antibodies. Antibodies against this protein were detected in sera of patients with acute intestinal and secondary forms of pseudotuberculosis.
About the Authors
N. M. Tishchenko
ФГБУ науки ТИБОХ им. Г.Б. Елякова ДВО РАН
Russian Federation
Russian Federation
S. I. Bakholdina
ФГБУ науки ТИБОХ им. Г.Б. Елякова ДВО РАН
Russian Federation
Russian Federation
O. J. Portnyagina
ФГБУ науки ТИБОХ им. Г.Б. Елякова ДВО РАН
Russian Federation
Russian Federation
O. N. Sofronova
ФБУЗ «Центр гигиены и эпидемиологии в РС (Я)»
Russian Federation
Russian Federation
K. V. Guzev
ФГБУ науки ТИБОХ им. Г.Б. Елякова ДВО РАН
Russian Federation
Russian Federation
A. V. Rakin
Институт гигиены и медицинской микробиологии
Germany
Germany
M. P. Isaeva
ФГБУ науки ТИБОХ им. Г.Б. Елякова ДВО РАН
Russian Federation
Russian Federation
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Review
For citations:
Tishchenko N.M., Bakholdina S.I., Portnyagina O.J., Sofronova O.N., Guzev K.V., Rakin A.V., Isaeva M.P. Genetic characteristics and antigenic properties of phospholipase α from outer membrane yersinia pseudotuberculosis. Yakut Medical Journal. 2012;(4):68-71. (In Russ.)
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