Relationship of CYP2E1 gene polymorphism and tolerability of ovarian cancer chemotherapy
Abstract
The response to chemotherapy and CYP2E1 polymorphism gene in groups of ovarian cancer patients and healthy women of Yakut ethnic group was analyzed. Significant differences in the frequency of allele CYP2E1 * 1D (96 bp insertion in the promoter region of the gene) were revealed. The higher content was observed in the group of healthy women.
About the Authors
F. G. Ivanova
ЯНЦ КМП СО РАМН;
ГБУ ЯРОД;
МЗ РС(Я)
Russian Federation
Russian Federation
N. V. Cherdyntseva
ФБГУ НИИ онкологии СО РАМН
Russian Federation
Russian Federation
A. V. Khrunin
ФБГУ Институт молекулярной генетики РАН
Russian Federation
Russian Federation
V. A. Gorbunova
ФБГУ РОНЦ им. Н.Н. Блохина РАМН
Russian Federation
Russian Federation
References
1. Molecular-genetic features of progression and response to therapy of malignant tumors: ethnical aspects / N.V. Cherduntseva, F.G. Ivanova, N.V.Litvyakov [et al.] //Medical genetics. - 2011, №10. - P.28-36.
2. Bolt H.M. The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine / H.M. Bolt, P.H. Roos, R. Thier // Int Arch Occup Environ Health. - 2003. V. 76, № 3. - P. 174-85.
3. Caro A.A. Oxidative stress, toxicology, and pharmacology of CYP2E1 /A.A. Caro, A.I.Cederbaum// Annu Rev Pharmacol Toxicol. – 2004. – V. 44. – P. 27-42.
4. Danko I.M. Association of CYP2E1 gene polymorphism with predisposition to cancer development / I.M. Danko, N.A. Chaschin. // Exp Oncol. – 2005. – V. 27, № 4. – P. 248-56.
5. Fritsche E. Localization, sequence analysis, and ethnic distribution of a 96-bp insertion in the promoter of the human CYP2E1 gene / E. Fritsche, G.S. Pittman, D.A. Bell.// Mutation Research Genomics. - 2000. - V. 432. - P. 1–5.
6. Gemma S. Individual susceptibility and alcohol effects:biochemical and genetic aspects /S. Gemma, S. Vichi, E. Testai // Ann Ist SuperSanita. – 2006. – V. 42, № 1. – P. 8-16.
7. Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients / A.V. Khrunin, A.Moisseev, V Gorbunova [et al.] //Pharmacogenomics J. - 2010. - V. 10, № 1. - P. 54-61.
8. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity / P. Neafsey, G. Ginsberg, D. Hattis [et al.] // J Toxicol Environ Health B Crit Rev. - 2009. - V. 12, № 5-6. - P. 362-88.
9. Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study / M. Morita, L. Le Marchand, Kono S. [et al.]// Cancer Epidemiol Biomarkers Prev. - 2009. - V. 18, № 1. - P. 235-41.
10. Liu K. Power Marker: an integrated analysis environment for genetic marker analysis / K. Liu, S.V. Muse // Bioinformatics. - 2005. - V. 21, № 9. - P. 2128-9.
11. Marchand L.L. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone./ L.L. Marchand, G.R. Wilkinson, L.R. Wilkens.// Cancer Epidemiol Biomarkers Prev. - 1999. - V. 8, № 6. - P. 495-500.
12. Milligan B.G. Total DNA isolation / B.G. Milligan // Molecular genetic analysis of populations / Ed. by A.R. Hoelzel. - London: Oxford University Press, 1998. - P. 29-60.
13. Role of the genetic polymorphisms in the 5'-flanking region for transcriptional regulation of the human CYP2E1 gene / T. Uchimoto, S. Itoga, M. Nezu, M. Sunaga [et al.] // Alcohol Clin Exp Res. - 2007. - V. 31, № 1 Suppl. - P. S36-42.
14. Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer / S. Itoga, F. Nomura, Y. Makino [et al.] // Alcohol Clin Exp Res. - 2002. - V. 26, № 8 Suppl. - P. 15S-19S.
15. Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene / F. Nomura, S. Itoga, T. Uchimoto [et al.] // Alcohol Clin Exp Res. - 2003. - V. 27, № 8 Suppl. - P. 42S-46S.
Review
For citations:
Ivanova F.G., Cherdyntseva N.V., Khrunin A.V., Gorbunova V.A. Relationship of CYP2E1 gene polymorphism and tolerability of ovarian cancer chemotherapy. Yakut Medical Journal. 2012;(4):35-37. (In Russ.)
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