Systemic juvenile idiopathic arthritis: the protective role of SSR5delta32mutation
Abstract
It is suspected that the prevalence in different ethnic groups of HLA-genotype and mutation CCR5delta32 – factors which alter adhesion of protein CCR5 – are the causes of different prevalence of juvenile idiopathic arthritis in different ethnic populations. The analysis of 234 DNAsamples (QIAamp Mini Kit) of patients with system onset juvenile idiopathic arthritis didn’t reveal any differences in prevalence of mutation in patients with soJIA, in patients with macrophage-activation syndrome and in total population. Our results do not support the idea of protective role of the mutation CCR5delta32 against soJIA, what can be explained also by probable association of soJIA with HLA-genotype or other factors of ethnicity. At the same time it can be considered as an additional evidence of expediency of soJIA being an original disease different from the rest of JIA group of diseases.
About the Authors
E. V. Fedorova
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
A. S. Egorov
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
T. Ammosova
Университет Говарда
United States
United States
S. L. Avrusin
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
A. Santimov
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
S. Nekhai
Университет Говарда
United States
United States
A. Grom
Детская больница
United States
United States
V. G. Chasnyk
Санкт-Петербургская государственная педиатрическая медицинская академия
Russian Federation
Russian Federation
T. E. Burtseva
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
F. V. Vinokourova
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Fedorova E.V., Egorov A.S., Ammosova T., Avrusin S.L., Santimov A., Nekhai S., Grom A., Chasnyk V.G., Burtseva T.E., Vinokourova F.V. Systemic juvenile idiopathic arthritis: the protective role of SSR5delta32mutation. Yakut Medical Journal. 2012;(4):14-17. (In Russ.)
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