Functional state of the cells of bronchoalveolar lavage fluid of patients with bronchitis asthma of varying severity
Abstract
The cellular composition of the oxidation-state of metabolic function and cytokine-producing activity of cells of bronchoalveolar (BAL) fluid of patients to clarify the mechanisms that determine the severity of the clinical course of bronchial asthma (BA) was studiedю
The increased number of neutrophils in BAL fluid of patients with asthma as the worsening of the disease was marked. Also it was found that with the worsening of the severity of BAL fluid cells of asthmatic patients secrete more Th2 cytokines profile. The authors substantiated the fact that these changes in the functional state of pulmonary cells are the basis of the mechanisms that determine the severity of the clinical course of asthma.
About the Authors
E. L. Lazutkina
Amur state medical academy
Russian Federation
Russian Federation
Elena L. Lazutkina, PhD, Associate Professor. Associate Professor, Department of Hospital Therapy
89619526361
675000, Blagoveshchensk, Gorkogo St., 95
Yu. S. Landyshev
Amur state medical academy
Russian Federation
Russian Federation
Yuriy S. Landyshev, MD, professor. Head of the Department of Hospital Therapy
89244499929
675000, Blagoveshchensk, Gorkogo St., 95
D. D. Tsyrendorzhiev
Scientific research institute of clinical immunology of Russian Academy of Medical Science
Russian Federation
Russian Federation
Dondok D. Tsyrendorzhiev, MD, Professor, Senior Researcher, Laboratory of Immunobiology Stem Cell Research Institute of Clinical Immunology
Tel: (383) 333-56-42
630091, Novosibirsk, Yadrintsevskaya St., 14
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Review
For citations:
Lazutkina E.L., Landyshev Yu.S., Tsyrendorzhiev D.D. Functional state of the cells of bronchoalveolar lavage fluid of patients with bronchitis asthma of varying severity. Yakut Medical Journal. 2012;(3):18-21.
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