Association of the PTGS2 polymorphism rs689466 with plasma irisin level in residents of Yakutia
https://doi.org/10.25789/YMJ.2023.82.20
Abstract
The aim of this study is to analyze the polymorphism rs689466 of the PTGS2 gene with the level of irisin in blood plasma in the population of Yakuts living in cold climatic conditions.
Irisin levels in men with TT genotype (8.2 ± 1.85 μg/ml) were significantly higher compared to men with CT+CC genotypes (7.1 ± 1.25 μg/ml; U=261; p = 0.005). In addition, men with the TT genotype had lower weight (63.6 ± 6.67 kg) than men with the CT+CC genotypes (67.93 ± 7.28 kg; U=279; p = 0.01). The detected association of the TT rs689466 genotype of the PTGS2 gene with elevated irisin levels and with a lower weight in men may indicate the effect of prostaglandin E2 on shivering thermogenesis during cold stress, which may play a role in human adaptation to cold climate.
Supporting agencies: The work was carried out within the framework of the research YANGTS KMP "Study of the genetic structure and burden of hereditary pathology in the populations of the Republic Sakha (Yakutia) and the State Assignment of the Ministry of Science and Higher Education of the Russian Federation (FSRG-2023-0003)
About the Authors
A. A. Nikanorova
Yakut Scientific Research Center of Complex Medicine problems
Russian Federation
Russian Federation
Yakutsk
N. A. Barashkov
Yakut Scientific Research Center of Complex Medicine problems
Russian Federation
Russian Federation
Yakutsk
V. G. Pshennikova
Yakut Scientific Research Center of Complex Medicine problems
Russian Federation
Russian Federation
Yakutsk
S. S. Nakhodkin
Institute of Natural Sciences Sciences NEFU named after. M.K. Ammosov
Russian Federation
Russian Federation
Yakutsk
S. A. Fedorova
Institute of Natural Sciences Sciences NEFU named after. M.K. Ammosov
Russian Federation
Russian Federation
Yakutsk
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Review
For citations:
Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Nakhodkin S.S., Fedorova S.A. Association of the PTGS2 polymorphism rs689466 with plasma irisin level in residents of Yakutia. Yakut Medical Journal. 2023;(2):81-84. https://doi.org/10.25789/YMJ.2023.82.20
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