Association of deletion polymorphisms of GSTM1 and GSTT1 genes with the degree of lung damage in elderly people after COVID-19
https://doi.org/10.25789/YMJ.2023.81.18
Abstract
A feature of the SARS-CoV-2 virus, unlike other respiratory infections affecting the human body, is a rather high virulence and mortality. It has been established that severe forms of the disease are more common in elderly people with concomitant diseases. It has been established that free radical lipid oxidation plays an essential role in the pathogenesis of COVID-19. The body's antioxidant defense system prevents damage to cells and tissues from initiating free radical reactions. The family of enzymes glutathione-S-transferase (GST; EC 2.5.1.18) is interesting for research. The aim of this work was to analyze the association of polymorphisms of the GSTM1 and GSTT1 genes with the degree of lung damage in elderly people who had COVID-19. A survey of 51 elderly volunteers who had coronavirus infection aged 60 to 75 years (average age: 64.470± 0.602 years) was conducted. Informed consent to the study was obtained from all participants of the study (according to the protocol of the Ethics Committee of the YSC CMP No. 52 dated March 24, 2021, decision 1). Identification of samples by the GSTT1 and GSTM1 genes was carried out using polymerase chain reaction (PCR) according to the method described in the work of Zehra et al. (2018). According to the data obtained by us, 74.50% of all surveyed elderly people suffered a coronavirus infection with a mild degree of lung damage, and 25.49% with a severe degree. The results of our study show that the combination of zero deletion genotypes GSTM1 and GSTT1 are a risk factor for the development of severe lung lesions in elderly people in Yakutia.
About the Authors
V. M. Nikolaev
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Nikolaev Vyacheslav Mikhailovich – PhD in Biology, senior researcher
E. K. Rumyantsev
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Rumyantsev Egor Konstantinovich – junior researcher
S. I. Sofronova
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Sofronova Sargylana Ivanovna – Ph.D., chief researcher, director of the department
S. D. Efremova
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Efremova Svetlana Dmitrievna – junior researcher
A. N. Romanova
Yakut Scientific Center of Complex Medical Problems
Russian Federation
Russian Federation
Romanova Anna Nikolaevna – MD, Director
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Review
For citations:
Nikolaev V.M., Rumyantsev E.K., Sofronova S.I., Efremova S.D., Romanova A.N. Association of deletion polymorphisms of GSTM1 and GSTT1 genes with the degree of lung damage in elderly people after COVID-19. Yakut Medical Journal. 2023;(1):71-74. https://doi.org/10.25789/YMJ.2023.81.18
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