The effect of obesity on sexual dimorphism of irisin levels
A. A. Nikanorova,
N. A. Barashkov,
V. G. Pshennikova,
N. N. Gotovtsev,
G. P. Romanov,
A. V. Solovyev,
S. S. Kuzmina,
N. N. Sazonov,
S. A. Fedorova https://doi.org/10.25789/YMJ.2022.79.04
Abstract
The aim of this study is to conduct a comparative analysis of average irisin levels between female and male (with normal weight and obese) to assess sexual dimorphism. Circulating levels of irisin in the blood of 279 Yakuts (185 female, 94 male, average age 19.8 ± 2.03 years) were determined. A comparative analysis of irisin levels between male and female in three BMI groups (underweight, normal weight, overweight/obesity) was carried out. The average level of irisin in the blood plasma in female was 8.33 ± 2.74 mcg/mL, and in male 7.76 ± 1.86 mcg/mL. Sexual dimorphism (p = 0.02) was detected in Yakuts with normal weight, where the level of irisin was higher in women (8.42 = 2.92 mcg/mL) compared to men (7.51 = 1.61 mcg/mL). Conducted a comparative analysis of irisin levels between male and female based on global data, were including this analysis are 2132 people. The age of the participants ranged from 18 to 61 years old. The meta-analysis was carried out for two different BMI groups: the first group included people with normal weight (18.5-24.9 kg/m2), the second group included people with varying degrees of obesity (>30 kg/m2). Comparative analysis of irisin levels in a large sample revealed statistically significant sexual dimorphism, where irisin levels were also higher in female compared to male, only in a sample of obese people (p = 0.02), in a sample of people with normal weight, no sexual differences were found (p = 0.09). Thus, the influence of obesity on sexual dimorphism was revealed.
About the Authors
A. A. Nikanorova
Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Nikanorova Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics
N. A. Barashkov
Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Barashkov Nikolay Alekseevich – Candidate of biological sciences, Head of laboratory of Molecular genetics
V. G. Pshennikova
Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics
N. N. Gotovtsev
Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Gotovtsev Nyurgun Naumovich – scientific researcher, Laboratory of Molecular Genetics
G. P. Romanov
Институт естественных наук СВФУ им. М.К. Аммосова
Russian Federation
Russian Federation
Romanov Georgii Prokopievich – Researcher, Research Laboratory of Molecular Biology, Institute of Natural Sciences
A. V. Solovyev
Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems
Russian Federation
Russian Federation
Soloviev Aisen Vasilyevich – Candidate of Biological Sciences, Senior Researcher, Research Laboratory of Molecular Biology, Institute of Natural Sciences
S. S. Kuzmina
Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov Northeastern Federal University
Russian Federation
Russian Federation
Kuzmina Sargylana Semenovna – Candidate of Biological Sciences, Associate Professor, Department of Biology,
N. N. Sazonov
Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov Northeastern Federal University
Russian Federation
Russian Federation
Sazonov Nikolay Nikitich – Doctor of biological sciences, Professor, Department of Biology
S. A. Fedorova
Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov Northeastern Federal University
Russian Federation
Russian Federation
Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences
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Review
For citations:
Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Gotovtsev N.N., Romanov G.P., Solovyev A.V., Kuzmina S.S., Sazonov N.N., Fedorova S.A. The effect of obesity on sexual dimorphism of irisin levels. Yakut Medical Journal. 2022;(3):16-20. https://doi.org/10.25789/YMJ.2022.79.04
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