The relationship between markers of metabolic syndrome and levels of specific IgG to food in healthy individuals and with metabolic syndrome
https://doi.org/10.25789/YMJ.2025.91.29
Abstract
Due to the steady increase in the incidence of metabolic syndrome (MetS), studying the ways to reduce the risk of its occurrence is an important task for modern medicine. The aim of the study is to identify the relationship of MetS markers with the levels of specific IgG to various products, as well as to assess the relationship of the content of proinflammatory cytokines and C-reactive protein with MetS. It is shown that for the examined individuals with MetS, more direct correlations are recorded and most often with the glucose level. Many products can provoke postprandial hyperglycemia, which in a practically healthy person will not cause significant disturbances, but with MetS, a failure of glucose and lipid homeostasis in combination with insulin resistance does not allow effective correction of blood glucose levels. Thus, when introducing elimination diets for MetS, it is necessary to take into account the possibility of postprandial hyperglycemia in this group of people, monitor glucose and insulin levels to prevent the development of insulin resistance.
About the Authors
V. P. Patrakeeva
ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова Уральского отделения РАН», Институт физиологии природных адаптаций
Russian Federation
Russian Federation
E. V. Kontievskaya
ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова Уральского отделения РАН», Институт физиологии природных адаптаций
Russian Federation
Russian Federation
V. A. Shtaborov
ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова Уральского отделения РАН», Институт физиологии природных адаптаций
Russian Federation
Russian Federation
A. V. Samodova
ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова Уральского отделения РАН», Институт физиологии природных адаптаций
Russian Federation
Russian Federation
References
1. Hypersensitivity to food antigens as a predictor of the development of metabolic syndrome / P.S. Novikov [et al.] // Cytokines and inflammation. 2016; No. 3-4(15): 280-284.
2. Karomatov I.D., Abdullayeva D.A. Black pepper and metabolic syndrome // Biology and integrative medicine. 2019; No. (34): 4-11.
3. Novikov P.S. The role of hyperreactivity to food antigens in the development of metabolic syndrome: Abstract of the dissertation of the Candidate of Medical Sciences. M. 2024.
4. Assessment of the content of specific IgG to food antigens in patients with metabolic syndrome / V.P. Patrakeeva [et al.] // Nutrition issues. 2023; Vol. 92. No. 6: 98-106. DOI: 10.33029/0042-8833-2023-92-6-98-10
5. Patrakeeva V.P., Shtaborov V.A. The role of nutrition and intestinal microflora in the formation of metabolic syndrome. // Obesity and metabolism. 2022; No. 3(19): 292-299. DOI: 10.14341/omet12893.
6. Tanchenko O.A., Naryshkina S.V., Reshetnikova L.K. Features of the immune status in patients with metabolic syndrome // Far Eastern Medical Journal. 2014; No. 2: 20-23.
7. Biong A.S., et al. A comparison of the effects of cheese and butter on serum lipids, haemostatic variables and homocysteine. Br J Nutr. 2004. Vol. 92(5). P. 791-7. DOI: 10.1079/bjn20041257.
8. Guo H, et al. Association of Red Meat and Poultry Consumption With the Risk of Metabolic Syndrome: A Meta-Analysis of Prospective Cohort Studies. Front Nutr. 2021. 8:8:691848. DOI: 10.3389/fnut.2021.691848.
9. Cen M, et al. Associations between metabolic syndrome and anxiety, and the mediating role of inflammation: Findings from the UK Biobank. Brain Behav Immun. 2024. Vol. 116. P.1-9. DOI: 10.1016/j.bbi.2023.11.019.
10. Singh B, et al. Bioactive constituents in pulses and their health benefits. J Food Sci Technol. 2017. Vol. 54(4). P. 858-870. DOI: 10.1007/s13197-016-2391-9.
11. Bjørnshave A., Hermansen K. Effects of dairy protein and fat on the metabolic syndrome and type 2 diabetes. Rev Diabet Stud. 2014. Vol. 11(2). P. 153-66. DOI: 10.1900/RDS.2014.11.153.
12. Timon C.M., et al. Dairy Consumption and Metabolic Health. Nutrients. 2020. Vol. 12(10):3040. DOI: 10.3390/nu12103040.
13. Mursu J, et al. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med. 2004. Vol. 37(9):1351-9. DOI: 10.1016/j.freerad-biomed.2004.06.002.
14. Ren Y, et al. Effect of fruit on glucose control in diabetes mellitus: a meta-analysis of nineteen randomized controlled trials. Front. Endocrinol. 2023. Vol. 14 – 2023. DOI: 10.3389/fendo.2023.1174545.
15. Du H., et al. Fresh Fruit Consumption and Major Cardiovascular Disease in China. N Engl J Med. 2016. Vol. 374(14):1332-43. DOI: 10.1056/NEJMoa1501451.
16. Grandl G., Wolfrum C. Hemostasis, endothelial stress, inflammation, and the metabolic syndrome. Semin Immunopathol. 2018. Vol. 40(2). P.215-224. DOI: 10.1007/s00281-017-0666-5.
17. Grath L., Fernandez M-L. Plant-based diets and metabolic syndrome: Evaluating the influence of diet quality. Journal of Agriculture and Food Research. 2022. 9:100322. https://doi.org/10.1016/j.jafr.2022.100322.
18. Hallfrisch J., Behall K.M. Mechanisms of the effects of grains on insulin and glucose responses. Am Coll Nutr. 2000. Vol. 19(3). P. 320-325. DOI: 10.1080/07315724.2000.10718967.
19. Esser N, et al. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 2014. Vol. 105(2). P. 141-50. DOI: 10.1016/j.diabres.2014.04.006.
20. Kim Y., Je Y. Meat Consumption and Risk of Metabolic Syndrome: Results from the Korean Population and a Meta-Analysis of Observational Studies. Nutrients.2018. Vol. 10(4):390. DOI: 10.3390/nu10040390.
21. Mendivil C.O. Fish Consumption: A Review of Its Effects on Metabolic and Hormonal Health // Nutr Metab Insights. 2021. 3:14:11786388211022378. eCollection 2021. DOI: 10.1177/11786388211022378.
22. Ford E.S., et al. Metabolic syndrome and risk of incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. Cardiovascular Diabetology. 2008. Vol.7. № 35. https://doi.org/10.1186/1475-2840-7-35.
23. Monteiro R., Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010:2010:289645. DOI: 10.1155/2010/289645.
24. Kim H. et al. Plant-based diets and incident metabolic syndrome: Results from a South Korean prospective cohort study. PLOS Med. 2020. Vol. 17(11):e1003371. DOI: https://doi.org/10.1371/journal.pmed.1003371.
25. Saltiel A.R., Olefsky J.M. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017. Vol. 127(1). P. 1-4. DOI: 10.1172/JCI92035.
26. Lorenzo C, Williams K, Hunt K. J., Haffner S.M. The National Cholesterol Education Program Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the Metabolic Syndrome as Predictors of Incident Cardiovascular Disease and Diabetes. Diabetes Care. 2007. No. 30(1). P. 8-13
27. Tokede O.A., Gaziano J.M., Djouss L. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr. 2011. Vol. 65(8). P. 879-86. DOI: 10.1038/ejcn.2011.64
28. Tørris C., Cvancarova S.M., Molin M. Nutrients in Fish and Possible Associations with Cardiovascular Disease Risk Factors in Metabolic Syndrome. Nutrients. 2018. Vol. 10(7):952. DOI: 10.3390/nu10070952.
Review
For citations:
Patrakeeva V.P., Kontievskaya E.V., Shtaborov V.A., Samodova A.V. The relationship between markers of metabolic syndrome and levels of specific IgG to food in healthy individuals and with metabolic syndrome. Yakut Medical Journal. 2025;(3):134-140. https://doi.org/10.25789/YMJ.2025.91.29
Views:
43
Email this article 