Ways to reduce allergy to cattle milk in Yakutia via gene β-lactoglobulin genotyping
Abstract
In order to reduce the incidence of milk allergy among residents of Yakutia, Russia we studied an allelic and genotype variation of betalactoglobulin gene of cattle breed in the Republic of Sakha (Yakutia). Allele distribution analysis of beta-lactoglobulin gene among the studied breeds demonstrated that the frequency of allele B prevails in Kholmogor cattle, local selection of Simmental cattle and especially in Kalmyk cattle. The genotype associated with the low content of milk serum proteins, and therefore hypoallergenic milk is BB genotype. This genotype was observed most often in cows of Kalmyk breed and cows of local Simmental breed.
The use of marker-assisted selection in dairy cattle will facilitate the increase in number of individuals with BB genotype of beta-lactoglobulin gene which is critical for the reduction of incidence of atopic allergies in the Republic of Sakha (Yakutia).
Keywords
About the Authors
N. I. Pavlova
Federal public educational institution of the higher education "Yakut state agricultural academy";
Federal public budgetary scientific institution "Yakut Scientific Center of Complex Medical Problems"
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna, Graduate student;
Junior researcher of laboratory of heritable pathology of department of molecular genetics
N. P. Filippova
Federal public educational institution of the higher education "Yakut state agricultural academy"
Russian Federation
Russian Federation
Filippova Natalya Pavlovna, Candidate of Biological sciences, associate professor of general zootechnics
Kh. A. Kurtanov
Federal public budgetary scientific institution "Yakut Scientific Center of Complex Medical Problems"
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich, Candidate of Medical sciences, head of the laboratory of heritable pathology of department of molecular genetics
V. A. Alekseev
Federal public budgetary scientific institution "Yakut Scientific Center of Complex Medical Problems"
Russian Federation
Russian Federation
Alekseev Vladislav Amirovich, Research associate of laboratory of Immunology
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Review
For citations:
Pavlova N.I., Filippova N.P., Kurtanov Kh.A., Alekseev V.A. Ways to reduce allergy to cattle milk in Yakutia via gene β-lactoglobulin genotyping. Yakut Medical Journal. 2016;(3):18-20.
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