Level of tumor markers in the population of Southern Yakutia consuming untreated and filtered water
https://doi.org/10.25789/YMJ.2025.91.04
Abstract
The level of tumor markers was assessed in working-age residents of the Aldan district who consume untreated and filtered water. The average level of tumor markers varied within the normal range. Residents of the city of Aldan who consume unpurified water have shown an increase in the average level of cancer embryonic antigen and carbohydrate antigen Ca19-9 compared to other groups. This group also has a high proportion of individuals with elevated levels of carbohydrate antigen Ca15-3, cancer embryonic antigen, and among women, carbohydrate antigen CA-125. Among individuals who consume filtered water, there is a high proportion of individuals with elevated levels of alpha-fetoprotein, which is more commonly found among residents of the city of Tommot, indicating a need for more in-depth study.
About the Authors
E. D. OkhlopkovaRussian Federation
A. A. Grigorieva
Russian Federation
S. D. Efremova
Russian Federation
L. I. Borisova
Russian Federation
S. I. Sofronova
Russian Federation
A. N. Romanova
Russian Federation
References
1. The impact of chemicals in drinking water on public health / E.O. Markova, Yu.P. Koryakina, N.F. Farashchuk, M.A. Keegan // Bulletin of the Smolensk State Medical Academy. 2023. Vol. 22. No. 1:239-249.
2. Доклад об экологической ситуации в Республике Саха (Якутия) в 2022 году. 62 с. Report on the environmental situation in the Republic of Sakha (Yakutia) in 2022. 62 p..https://datahub.sakha.gov.ru/form/files/org_302/dataout/form6_org302_obj8613_date2023-11-03_2.%20Доклад%20об%20Экологической%20ситуации%20в%20РС(Я)%202022%20краткий_04.07.23.pdf.
3. Report "On the state of public health and healthcare organization in the Republic of Sakha (Yakutia) based on the results of activities for 2022" Yakutsk 2023. 177c. https://minzdrav.sakha.gov.ru/uploads/ckfinder/userfiles/2023/12/12/files/Доклад%20о%20сост_%20здоровья%202022_657824d8aa648.pdf
4. Efremova S.D., Golderova A.S., Krivoshapkina Z.N. et al. Water hardness and its relationship with the level of cancer markers in residents of Yakutia // Yakut Medical Journal. 2018No. 3(63):37-39.
5. Zazdravnaya A.V. Cancer markers and their clinical significance //Ugra healthcare: experience and innovations. 2016; 2: 26-32. https://cyberleninka.ru/article/n/onkomarkery-i-ih-klinicheskoe-znachenie
6. Zolotorevskaya O.S., Elgina S.I., Timaeva A.I. Diagnostic significance of the tumor marker CA125 in the early stages of ovarian cancer diagnosis // Mother and Child in Kuzbass. 2020. No. 3 (82): 51-55.
7. Krivoshapkin V.G., Timofeev L.F. Medical and environmental monitoring in the area of activity of mining enterprises in the Republic of Sakha (Yakutia) // Yakut Medical Journal. 2018. No. 3: 52-53
8. Rashidova, D.A. Khasanova, M.T. Oncomers in oncology: biochemical aspects of carcinogenesis, definition of treatment strategies, development of innovative diagnostic methods // Oriental renaissance: Innovative, educational, natural and social sciences. 2024. 4(4): 186-194.
9. СА 19-9 https://helix.ru/kb/item/08-006
10. Solenova L.G. Modern approaches to assessing the impact of environmental pollution on cancer risk // Advances in Molecular Oncology. 2020. Vol. 7. No. 1: 17-22.
11. Solomatina T.V. Cancer markers as a risk factor in areas of ecological distress // Bulletin of Siberian medicine. 2002. No. 1. pp.114-117.
12. Comparative characteristics of the level of tumor markers in residents of Yakutia in areas of ecological trouble / V.M. Nikolaev, S.D. Efremova, A.S. Golderova, et al. // Bulletin of the SB RAMS. 2011; 3(79), part 1: 86-88.
13. Ecological dependence of the spread of oncological diseases in Primorsky Krai / L.V. Veremchuk, P.F. Kikul, M.V. Zhernovoy, S.V. Yudin // Siberian oncological journal. 2012. No. 16:19-25.
14. Yagudina L.A. Novozhilova A.A. Immunodiagnostics of tumors // Medical Almanac 2016. 2(42): 48-52.
15. Kaur G., Kumar R., Mittal S., Sahoo P. K., & Vaid U. Ground/drinking water contaminants and cancer incidence: A case study of rural areas of South West Punjab, India / Human and Ecological Risk Assessment: An International Journal. 2021. 27(1): 205–226. https://doi.org/10.1080/10807039.2019.1705145
Review
For citations:
Okhlopkova E.D., Grigorieva A.A., Efremova S.D., Borisova L.I., Sofronova S.I., Romanova A.N. Level of tumor markers in the population of Southern Yakutia consuming untreated and filtered water. Yakut Medical Journal. 2025;(3):20-23. (In Russ.) https://doi.org/10.25789/YMJ.2025.91.04