Comparative analysis of the 5-HTTLPR polymorphism of SLC6A4 gene in Russian and Yakut populations
https://doi.org/10.25789/YMJ.2025.91.03
Abstract
The 5-HTTLPR polymorphism of the SLC6A4 gene plays a key role in the regulation of serotonergic transmission and may influence susceptibility to anxiety and depressive disorders. This study presents a comparative analysis of the distribution of genotypes and alleles of this polymorphism in representatives of the Russian (n = 250) and Yakut (n = 260) ethnic groups. A significantly higher prevalence of the S allele (77.7%) and the homozygous SS genotype (63.8%) was observed in the Yakut population compared to the Russian group (44.8% and 20.8%, respectively; p < 0.001). The Russian sample was characterized by a higher frequency of the L allele and the SL genotype. The identified differences reflect the high frequency of the S allele characteristic of the Indigenous peoples of Siberia and underscore the ethnic specificity of genetic factors involved in psycho-emotional regulation.
About the Authors
A. V. Krylov
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
N. I. Pavlova
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
A. A. Bochurov
ФГБНУ «Якутский научный центр комплексных медицинских проблем»
Russian Federation
Russian Federation
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Review
For citations:
Krylov A.V., Pavlova N.I., Bochurov A.A. Comparative analysis of the 5-HTTLPR polymorphism of SLC6A4 gene in Russian and Yakut populations. Yakut Medical Journal. 2025;(3):16-19. (In Russ.) https://doi.org/10.25789/YMJ.2025.91.03
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