Immunohistochemical analysis of epithelial cells in mammary tumors in Republic Sakha (Yakutia)
Abstract
The analysis of results of histological research of operational materials from 294 women with the breast cancer with the subsequent immunohistochemistry (IHC) definition of estrogen (ER) – and progesterone (PgR) – receptors, proliferative activity (Ki-67) expression of mutation suppressor gene (p53) and gene-inhibitor of apoptosis (bcl-2) was carried out. The obtained data testify that IHC-research of the tumor progression markers is a defining part in the forecast of course, optimization of therapeutic approaches with an individualization of chemo-, hormonal and beam therapy of mammary cancer, the decision of a question of medicamentous and/or surgical shutdown of the ovaries, based on the research results of the biological activity markers of the tumor.
About the Authors
M. P. Kirillina
Медицинского института СВФУ им. М.К. Аммосова; ЯНц КМП СО РАМН
Russian Federation
Russian Federation
K. S. Loskutova
ЯНц КМП СО РАМН; МЗ РС(Я)
Russian Federation
Russian Federation
E. L. Lushnikova
НИИ региональной патологии и патоморфологии СО РАМН
Russian Federation
Russian Federation
L. M. Nepomnyashchikh
НИИ региональной патологии и патоморфологии СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Kirillina M.P., Loskutova K.S., Lushnikova E.L., Nepomnyashchikh L.M. Immunohistochemical analysis of epithelial cells in mammary tumors in Republic Sakha (Yakutia). Yakut Medical Journal. 2014;(3):4-8.
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