Dehydroepiandrosterone: Biomarker of Senescence. Biosynthesis and Regulating Mechanisms
Abstract
This review presents and summarizes the results of recent studies on dehydroepiandrosterone (DHEA) which plays an important role in longevity regulation. During ontogenesis DHEA and DHEA-sulfate content steadily declines. At the same time, the mechanisms regulating secretion of these hormones and factors determining their age dynamics remain largely unsolved. The paper presents different mechanisms of regulation of adrenal secretion of DHEA and DHEA-sulfate involving adrenocorticotropic hormone (ACTH), prolactin, luteinizing hormone and insulin.
About the Authors
N. P. Goncharov
Endocrinology Research Center, Ministry of Health and Social Development of Russia
Russian Federation
Russian Federation
Nikolay P. Goncharov - Prof., MD, Head, Laboratory of Hormonal Analysis
Moscow
G. V. Katsiya
Endocrinology Research Center, Ministry of Health and Social Development of Russia
Russian Federation
Russian Federation
Gulinara V. Katsiya - MD, Main Scientist, Laboratory of Hormonal Analysis
Moscow
S. S. Nakhodkin
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Sergey S. Nakhodkin - Junior Scientist, Laboratory of Molecular Biology, Institute of Natural Sciences
Yakutsk
T. E. Burtseva
YSC CMP SB RAMS
Russian Federation
Russian Federation
Tatyana E. Burtseva – MD, deputy director
S. A. Fedorova
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Sardana A. Fedorova - Ph.D, Head, Laboratory of Molecular Biology, Institute of Natural Sciences
Yakutsk
References
1. Goncharov N.P. Corticos-teroids: metabolism, mechanism of action and clinical application / N.P. Goncharov, G.S. Kolesnikova. – M., izd Adamnt, 2002. - P.62-75.
2. Metabolism of androgens in male patients with type 1 diabetes / N.P. Goncharov, G.V. Katsiya, S.Y. Kalinchenko [et al.] // Problems of Endocrinology - 2001. - №4. - P.23-27.
3. Role of ACTH in the regulation of secretion of DHEA in primates / G.V. Katsiya, V.M Gorlushkin, T.N Todua [et al.] // Problems of Endocrinology. - 1990. - №1. - P.58-61.
4. Levels of glucocorticoids and adrenal androgens late after adrenalectomy / N.P. Goncharov, G.S. Kolesnikova, V.I. Vorontsov [et al.] // Problems of Endocrinology. - 1995. - №24. - P.27.
5. Habiner J.F. Synthesis and secretion of hormones / J.F. Habiner // Endocrinology and Metabolism: translated from english. - M., Medicine. - 1985. - P.60-113.
6. A genetic component to the variation of dehydroepiandrosterone sulfate / J.I. Rotter, F.L. Wong, E.T. Lifrak [et al.] // The Journal of Clinical Endocrinology and Metabolism. – 1985. - 34(8). – P.731-736.
7. Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man / P. Ebeling, U.H. Stenman, M. Seppala [et al.] // Jbid. – 1995. - 146(1). - P.63-69.
8. Adrenal function in preterm infants: ACTH may not be the sole regulator of the fetal zone / P.C. Midgley, K. Russell, N. Oates [et al.] // Pediatric Research. – 1998. – Dec.44(6). – P.887- 93.
9. Albright F. Syndrome characterized by primary ovarian insufficiency and desreased stature. Report of 11 cases with a digression on hormonal control of axillary and pubic hair / F. Albright, P.H. Smith, R.A. Frazer // The American Journal of the Medical Sciences. – 1942. – 204. – P.625-648.
10. Bornstein S.R. Clinical review 104: Adrenocorticotropin (ACTH) -and non ACTH -mediated regulation of the adrenal cortex: neural and immune imputs / S.R. Bornstein, G.P. Chorousos // Jbid. – 1999. – 84. – P.1729-1736.
11. Changes in concentrations of cortisol, DHAS and progesterone in fetal and maternal serum during pregnancy / A. Donaldson, U. Nicolini, E. Symes [et al.] // Jbid. – 1991. – 35. – P.447-451.
12. Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men / A. Belanger, B. Candas, A. Dupont [et al.] // Jbid. - 1994. - 79(4). - P.1086- 1090.
13. Dissociation of cortisol and adrenal androgen secretion in the hypophysectomized, ACTH-replaced chimpanzee / B. Albertson, W. Hobson, B. Burnett [et al.] // Jbid. - 1984. – 59. – P.13-19.
14. Dissociation of cortisol and androgen secretion in patients with secondary adrenal insufficiency / G.B.Jr. Culter, S.E. Davis, R.E. Johnsonbaugh [et al.] // Jbid. – 1979. - 49(1-3). – р.604-609.
15. Effect of insulin on serum levels of dehydroepiandrosterone metabolites in men / B. Lavallee, P.R. Provost, Z. Kahwash [et al.] // Jbid. – 1997. - 46(1). – P.93-100.
16. Effects of insulin reduction with benfluorex serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men / J.E. Nestler, N.A. Beer, D.J. Jakubowicz [et al.] // Jbid. – 1995. - 80(2). – P.700-706.
17. Functional aspects of the effect of prolactin (PRL) on adrenal steroidogenesis and distribution of the PRL receptor in the human adrenal gland / A. Glasow, M. Breidert, A. Haidan [et. al.] // Jbid. – 1996. – 81. – P.3103-3111.
18. Goncharov N.P. Adrenal and gonadal steroid levels in long-living males from highland regions of the Southwestern Caucasian Mountains / N.P.Goncharov, G.V. Katzya // The Aging. – 1998. – Male.1 – р.200-205.
19. Hyperglycemia decreases dehydroepiandrosterone in Japanese male with impaired glucose tolerance and low insulin response / A. Yamauchi, I. Takei, S. Nakamoto [et al.] // The Journal of Clinical Endocrinology and Metabolism. – 1996. - 43(3). – P.285-290.
20. Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis / G. Päth, S.R. Bornstein, M. Ehrhart - Bornstein [et al.] // Jbid. – 1997. – 82. – P.2343–2349.
21. Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies / J. Buster, R. Chang, D. Preston [et al.] // Jbid. - 1979. – 48. – P.139-149.
22. Koryakin M. The possible role of prolactin in adrenal androgens regulation / M. Koryakin, N. Goncharov, A. Akopyan // International Congress on Andrology. – Montreal. 2001.
23. Lack of correlation between gonadotropin and adrenal androgen levels in agonadal children / P.A. Lee, A. Kowarski, C.J. Migeon [et al.] // The Journal of Clinical Endocrinology and Metabolism. – 1975. - 40(4). - P.664-669.
24. Lymphocytes stimulate dehydroepia-ndrosterone production through direct cellular contact with adrenal zona reticularis cells:a novel mechanism of immuno-endocrine interaction / W.G. Wolkersdorfer, T. Lohmann, Ch. Marx [et al.] // Jbid. – 1999. – 84. – P.4220-4227.
25. Maternal and amniotic fluid steroids throughout human pregnancy / M. Nagamani, P. McDonough, J. Ellegood [et al.] // American Journal of Obstetrics and Gynecology. - 1979. – 134. - P.674-683.
26. Miller W.L. The molecular basis of premature adrenarche: a hypothesis / Miller W.L. // Acta Paediatrica, International Journal of Paediatrics, Supplement. – 1999. - 88(433). – р.60-66.
27. Novel presence of luteinizing hormone/ chorionic gonadotropin receptors in human adrenal glands / J.E Pabon, X. Li, Z.M. Lei [et al.] // The Journal of Clinical Endocrinology and Metabolism. – 1996. – Jun.81(6). – P.2397-400.
28. Parker L.N. A 60,000 molecular weight human pituitary glycopeptide stimulates adrenal androgen secretion / L.N. Parker, E.T. Lifrak, W.D. Odell // Jbid. – 1983. - 113(6). – р.2092-2096.
29. Plasma androgens in women with hyperprolactinaemic amenorrhoea / F. Bassi, G. Giusti, L. Borsi [et. al.] // Jbid. (Oxf). – 1977. - 6(1). – P.5-10.
30. Relevance of major Histocompatibility Complex Class II expression as a hallmark for the cellular differentiation in the human adrenal cortex / Ch. Marx, S.R. Bornstein, W.G. Wolkersdorfer [et al.] // Jbid. – 1997. – 82. – P.1136-1140.
31. Serum dehydroepiandrosterone sulfate levels as an individual marker / G. Thomas, N. Frenoy, S. Legrain [et al.] // Jbid. - 1994, - 79(5): - P.1273-1276.
32. Sex differences in the twenty-four-hour mean plasma concentrations of dehydroisoandrosterone (DHA) and dehydroisoandrosterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults / B. Zumoff, R.S. Rosenfeld, G.W. Strain [et al.] // Jbid. – 1980. - 51(2). – P.330-333.
33. Steroid hormone receptors in adrenal glands of fetal and adult rhesus monkeys / J. Hirst, N. West, R Brenner [et al.] // Jbid. - 1992. – 75. – P.308-314.
34. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men / A.E. Field, G.A. Colditz, W.C. Willett [et al.] // Jbid. - 1994. - 79(5). – P.1310-1316.
35. Vermeulen A. Adrenal androgens and aging / A. Vermeulen. – London: Academic Press. - 1980. - P.201-217.
36. Vermeulen A. Dehydroepiandrosterone sulfate and aging / A. Vermeulen // Ann N Y Acad Sci. – 1995. - Dec.29(774). - P.121-127.
37. Yuen B. HCG, prolactin, estriol and DHAS concentrations in cord blood of premature and term newborn infants / B. Yuen, E. Mincey // American Journal of Obstetrics and Gynecology. - 1987. – 156. – P.396-401.
Review
For citations:
Goncharov N.P., Katsiya G.V., Nakhodkin S.S., Burtseva T.E., Fedorova S.A. Dehydroepiandrosterone: Biomarker of Senescence. Biosynthesis and Regulating Mechanisms. Yakut Medical Journal. 2014;(1):52-56.
Views:
19
Email this article 